Preclinical data and small clinical trials suggest that remote ischaemic conditioning (RIC) therapy protects patients with acute myocardial infarction undergoing percutaneous coronary intervention. In the CONDI-2/ERIC-PPCI trial, RIC proved to be safe but did not have any short-term benefits in reducing cardiac-related death and hospitalization for heart failure.
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References
Hausenloy, D. J. et al. Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery. Basic Res. Cardiol. 111, 70 (2016).
Hausenloy, D. J. et al. Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial. Lancet https://doi.org/10.1016/S0140-6736(19)32039-2 (2019).
Jolly, S. S. et al. Outcomes after thrombus aspiration for ST elevation myocardial infarction: 1-year follow-up of the prospective randomised TOTAL trial. Lancet 387, 127–135 (2016).
Fabris, E. et al. One-year mortality for bivalirudin versus heparins plus optional glycoprotein IIb/IIIa inhibitor treatment started in the ambulance for ST-segment elevation myocardial infarction: a secondary analysis of the EUROMAX randomized clinical trial. JAMA Cardiol. 2, 791–796 (2017).
Eitel, I. et al. Cardioprotection by combined intrahospital remote ischaemic perconditioning and postconditioning in ST-elevation myocardial infarction: the randomized LIPSIA CONDITIONING trial. Eur. Heart J. 36, 3049–3057 (2015).
Thrane, P. G. et al. 16-year follow-up of the Danish Acute Myocardial Infarction 2 (DANAMI-2) trial: primary percutaneous coronary intervention versus fibrinolysis in ST-segment elevation myocardial infarction. Eur. Heart J. https://doi.org/10.1093/eurheartj/ehz595 (2019).
Rosselló, X. et al. Global geographical variations in ST-segment elevation myocardial infarction management and post-discharge mortality. Int. J. Cardiol. 245, 27–34 (2017).
Moran, A. E. et al. Temporal trends in ischemic heart disease mortality in 21 world regions, 1980 to 2010: the Global Burden of Disease 2010 study. Circulation 129, 1483–1492 (2014).
Yellon, D. M. et al. remote ischemic conditioning reduces myocardial infarct size in STEMI patients treated by thrombolysis. J. Am. Coll. Cardiol. 65, 2764–2765 (2015).
Cour, M. et al. Remote ischemic conditioning in septic shock (RECO-Sepsis): study protocol for a randomized controlled trial. Trials 20, 281 (2019).
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Cour, M., Lecour, S. Remote ischaemic conditioning: in search of a suitable match. Nat Rev Cardiol 16, 704–705 (2019). https://doi.org/10.1038/s41569-019-0296-9
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DOI: https://doi.org/10.1038/s41569-019-0296-9
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