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SEXUAL MEDICINE

Oxytocin antagonists: the next frontier in PE treatment

Oxytocin antagonists seem to have potential as a treatment option for premature ejaculation (PE), but the parameters of their use are vague. Two recently published studies highlight the need for large-scale trials to elucidate the value of these drugs in the treatment of PE.

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References

  1. Saitz, T. R. & Serefoglu, E. C. The epidemiology of premature ejaculation. Transl Androl. Urol. 5, 409–415 (2016).

    Article  Google Scholar 

  2. Saitz, T. R. & Serefoglu, E. C. Advances in understanding and treating premature ejaculation. Nat. Rev. Urol. 12, 629–640 (2015).

    Article  CAS  Google Scholar 

  3. Giuliano, F. & Clement, P. Pharmacology for the treatment of premature ejaculation. Pharmacol. Rev. 64, 621–644 (2012).

    Article  CAS  Google Scholar 

  4. Veening, J. G. et al. The role of oxytocin in male and female reproductive behavior. Eur. J. Pharmacol. 15, 209–228 (2014).

    Google Scholar 

  5. Shinghal, R. et al. Safety and efficacy of epelsiban in the treatment of men with premature ejaculation: a randomized, double-blind, placebo-controlled, fixed-dose study. J. Sex. Med. 10, 2506–2517 (2013).

    Article  CAS  Google Scholar 

  6. McMahon, C. et al. PD69-01 a phase IIa study to investigate the efficacy and safety of the selective oxytocin receptor antagonist, IX-01, in men with lifelong premature ejaculation. J. Urol. 197, e1344 (2017).

    Article  Google Scholar 

  7. Osterloh, I. H. et al. Pharmacokinetics, safety, and tolerability of single oral doses of a novel oxytocin receptor antagonist-cligosiban-in development for premature ejaculation: three randomized clinical trials in healthy subjects. J. Sex. Med. 15, 1547–1557 (2018).

    Article  Google Scholar 

  8. Wayman, C. et al. Cligosiban, a novel brain-penetrant, selective oxytocin receptor antagonist, inhibits ejaculatory physiology in rodents. J. Sex. Med. 15, 1698–1706 (2018).

    Article  Google Scholar 

  9. McMahon, C. et al. The oxytocin antagonist cligosiban prolongs intravaginal ejaculatory latency and improves patient-reported outcomes in men with lifelong premature ejaculation: results of a randomized, double-blind, placebo-controlled proof-of-concept trial (PEPIX). J. Sex. Med. 16, 1178–1187 (2019).

    Article  Google Scholar 

  10. Althof, S. et al. The oxytocin antagonist cligosiban fails to prolong intravaginal ejaculatory latency in men with lifelong premature ejaculation: results of a randomized, double-blind, placebo-controlled phase IIb trial (PEDRIX). J. Sex. Med. 16, 1188–1198 (2019).

    Article  Google Scholar 

Download references

Acknowledgements

M.G. is supported by the European Urological Scholarship Programme (EUSP) for his post-doctoral andrology fellowship training

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Correspondence to Ege Can Serefoglu.

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Gul, M., Serefoglu, E.C. Oxytocin antagonists: the next frontier in PE treatment. Nat Rev Urol 16, 696–697 (2019). https://doi.org/10.1038/s41585-019-0238-7

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