In this issue, Diehl et al. report that exogenous serine is essential for the cellular redox state and cancer nucleotide production, despite the ability of cancer cells to synthesize serine de novo in vitro.
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C.V.D. serves on the boards of Rafael Pharmaceuticals, Inc., Dracen Pharmaceuticals, Inc. and Polaris Pharmaceuticals, Inc.
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Dang, C.V. Essentiality of non-essential amino acids for tumour cells and tumorigenesis. Nat Metab 1, 847–848 (2019). https://doi.org/10.1038/s42255-019-0113-0
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DOI: https://doi.org/10.1038/s42255-019-0113-0
