Enhanced visualization of cell surface glycans via a hybridization chain reaction

Xiaohong Wen; Baoyin Yuan; Junxun Zhang; Xiangxian Meng; Qiuping Guo; Lie Li; Zenghui Li; Huishan Jiang; Kemin Wang

doi:10.1039/C9CC02069A

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Enhanced visualization of cell surface glycans via a hybridization chain reaction†

Xiaohong Wen,‡^a Baoyin Yuan,‡^a Junxun Zhang,^a Xiangxian Meng,^a Qiuping Guo,*^a Lie Li,^a Zenghui Li,^a Huishan Jiang^a and Kemin Wang

*^a

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* Corresponding authors

^a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, China
E-mail: guoqping@126.com, kmwang@hnu.edu.cn

Abstract

Herein, we apply a DNA hybridization chain reaction (HCR) to achieve sensitively amplified imaging of cell surface glycosylation with reduced non-natural monosaccharide units. This method is simple, efficient, sensitive, and possesses great potential to illuminate the pathways via which cell surface glycosylation regulates cell functions.

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Article information

DOI: https://doi.org/10.1039/C9CC02069A
Article type: Communication
Submitted: 14 Mar 2019
Accepted: 25 Apr 2019
First published: 26 Apr 2019

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Chem. Commun., 2019,55, 6114-6117

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Enhanced visualization of cell surface glycans via a hybridization chain reaction

X. Wen, B. Yuan, J. Zhang, X. Meng, Q. Guo, L. Li, Z. Li, H. Jiang and K. Wang, Chem. Commun., 2019, 55, 6114 DOI: 10.1039/C9CC02069A

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Chemical Communications

Enhanced visualization of cell surface glycans via a hybridization chain reaction†

Abstract

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Enhanced visualization of cell surface glycans via a hybridization chain reaction

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