Issue 46, 2024

Rational design of pH-responsive near-infrared spirocyclic cyanines: the effects of substituents and the external environment

Abstract

pH-responsive spirocyclic cyanine dyes were designed and synthesized. The equilibrium constant for cyclization (pKcycl) could be rationally controlled by changing the nucleophilic moiety and the side chains. Encapsulation in polymeric micelles inhibited the H-aggregation of the dye, and the pKcycl could be shifted according to the amphiphilic polymer employed.

Graphical abstract: Rational design of pH-responsive near-infrared spirocyclic cyanines: the effects of substituents and the external environment

Supplementary files

Article information

Article type
Communication
Submitted
01 Apr 2024
Accepted
13 May 2024
First published
13 May 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 5984-5987

Rational design of pH-responsive near-infrared spirocyclic cyanines: the effects of substituents and the external environment

A. Sakama, H. Seo, J. Hara, Y. Shindo, Y. Ikeda, K. Oka, D. Citterio and Y. Hiruta, Chem. Commun., 2024, 60, 5984 DOI: 10.1039/D4CC01484G

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