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Synthesis and Structural Study of Cytisinylphenylacetic Acid Nitriles

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Chemistry of Natural Compounds Aims and scope

Nitriles of stereoisomeric cytisinylarylacetic acids were synthesized by reacting cytisine with aromatic aldehydes in the presence of acetone cyanohydrin. Nitriles of cytisinylphenylacetic acids with the R- and S-configuration of the arylacetonitrile fragment were shown to be formed regioselectively in basic solution. The absolute configurations of the synthesized products were established using NMR spectroscopy and X-ray crystal structure analyses.

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Author notes

  1. Kh. M. Shakhidoyatov is Deceased

Authors and Affiliations

  1. S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 77 Mirzo Ulugbek St., 100170, Tashkent, Uzbekistan

    D. S. Ismailova, U. S. Makhmudov, Kh. M. Bobakulov, B. Zh. Elmuradov, A. A. Kadirov, Kh. M. Shakhidoyatov & B. Tashkhodzhaev

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  1. D. S. Ismailova
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  2. U. S. Makhmudov
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  3. Kh. M. Bobakulov
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  4. B. Zh. Elmuradov
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  5. A. A. Kadirov
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  6. Kh. M. Shakhidoyatov
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Correspondence to B. Zh. Elmuradov.

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Translated from Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2024, pp. 258–262.

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Ismailova, D.S., Makhmudov, U.S., Bobakulov, K.M. et al. Synthesis and Structural Study of Cytisinylphenylacetic Acid Nitriles. Chem Nat Compd 60, 291–296 (2024). https://doi.org/10.1007/s10600-024-04305-7

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  • DOI: https://doi.org/10.1007/s10600-024-04305-7

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