Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice

Shiwei Yao; Hongling Lu; Tianhuan Zhou; Qihong Jiang; Chenkai Jiang; Wenjun Hu; Mingqian Li; Chin Ping Tan; Yongcai Feng; Qun Du; Guoxin Shen; Xingwei Xiang; Lin Chen

doi:10.1039/D3FO04527G

Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice†

Shiwei Yao,‡^abc Hongling Lu,‡^b Tianhuan Zhou,^d Qihong Jiang,^b Chenkai Jiang,^b Wenjun Hu,^b Mingqian Li,^e Chin Ping Tan,^fg Yongcai Feng,^g Qun Du,^d Guoxin Shen,

^b Xingwei Xiang*^ac and Lin Chen

*^b

Author affiliations

* Corresponding authors

^a College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China
E-mail: xxw11086@126.com

^b Institute of Sericulture and Tea Research, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang 310021, China
E-mail: chenlinsdau@163.com

^c Zhejiang Key Laboratory of Green, Low-Carbon and Efficient Development of Marine Fishery Resources, Hangzhou 310014, China

^d Zhejiang Forest Resources Monitoring Center, Hangzhou, Zhejiang, China

^e Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China

^f Department of Food Technology, Faculty of Food Science and Technology, University Putra Malaysia, 43400 Serdang, Malaysia

^g Xujing (Hangzhou) Biotechnology Research Institute Co., Ltd., Hangzhou, Zhejiang 310021, China

Abstract

High-fat diet (HFD) has been associated with certain negative bone-related outcomes, such as bone metabolism disruption and bone loss. Sciadonic acid (SC), one of the main nutritional and functional components of Torreya grandis seed oil, is a unique Δ5-unsaturated-polymethylene-interrupted fatty acid (Δ5-UPIFA) that has been claimed to counteract such disorders owing to some of its physiological effects. However, the role of SC in ameliorating bone metabolism disorders due to HFD remains unclear. In the present investigation, we observed that SC modulates the OPG/RANKL/RANK signaling pathway by modifying the lipid metabolic state and decreasing inflammation in mice. In turn, it could balance bone resorption and formation as well as calcium and phosphorus levels, enhance bone strength and bone mineral density (BMD), and improve its microstructure. In addition, SC could inhibit fat vacuoles in bone, reverse the phenomenon of reduced numbers and poor continuity of bone trabeculae, and promote orderly arrangement of collagen fibers and cartilage repair. This study provides some theoretical basis for SC as a dietary intervention agent to enhance bone nutrition.

Food & Function

Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice†

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Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice

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