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Evaluating the effect of glycerol on increasing the safety and efficiency of hyperthermic laser lipolysis

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Abstract

This study aimed to investigate the effect of glycerol as an Optical Clearing Agent on the temperature profile of the skin during HyperThermic Laser Lipolysis using computer simulation. In this study, a three-layer model of the skin was used to simulate HyperThermic Laser Lipolysis. The Monte Carlo MCML code was used to investigate the propagation of laser photons inside skin tissue. The energy absorbed from photons is used as a heat source to determine the increase in temperature and assess thermal damage in the layers of the skin. The finite element method in COMSOL software was used for calculation. The simulation of single-pulse radiation exposure with and without applying glycerol to the skin model was investigated to assess the impact of glycerol. Glycerol decreases the temperature and thermal damage to the epidermis layer while increasing the temperature of the fat layer. Moreover, the presence of glycerol increases the depth of fat cell destruction. Glycerol, as a supplement, significantly improves the efficacy of HyperThermic Laser Lipolysis.

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Authors and Affiliations

  1. Department of Medical Physics and Biomedical Engineering, School of Medicine, Shiraz University of Medical Sciences, Zand Blvd., Shiraz, Fars, 71, Iran

    Afsane Vahidian, Alireza Mehdizadeh & Mohsen Ostovari

  2. Department of Physics, Shiraz University of Technology, Modarres Blvd., Shiraz, Fars, 71, Iran

    Parvaneh Momayezan Marnani

  3. Department of Radiology Technology, School of Allied Medical Sciences, Lorestan University of Medical Sciences, Goldasht, Khorramabad, Lorestan, 66, Iran

    Abbas Rezaeian

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  1. Afsane Vahidian
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  2. Parvaneh Momayezan Marnani
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  4. Abbas Rezaeian
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  5. Mohsen Ostovari
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Correspondence to Mohsen Ostovari.

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Vahidian, A., Momayezan Marnani, P., Mehdizadeh, A. et al. Evaluating the effect of glycerol on increasing the safety and efficiency of hyperthermic laser lipolysis. Lasers Med Sci 39, 84 (2024). https://doi.org/10.1007/s10103-024-04029-8

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  • DOI: https://doi.org/10.1007/s10103-024-04029-8

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