Skip to main content

Advertisement

Log in

Missing Nuts and Bolts: Translating Pulmonary Fibrosis from Preclinical Murine Models to Human Clinical Trials

  • CORRESPONDENCE
  • Published:
Lung Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Data Availability

No datasets were generated or analysed during the current study.

References

  1. Chang A, Van Ry PM, Raghu G (2023) Idiopathic pulmonary fibrosis: aligning murine models to clinical trials in humans. Lancet Respir Med 11(11):953–955

    Article  PubMed  Google Scholar 

  2. Rodt T, von Falck C, Dettmer S et al (2010) Micro-computed tomography of pulmonary fibrosis in mice induced by adenoviral gene transfer of biologically active transforming growth factor-beta1. Respir Res 11(1):181

    Article  PubMed  PubMed Central  Google Scholar 

  3. Devos FC, Maaske A, Robichaud A et al (2017) Forced expiration measurements in mouse models of obstructive and restrictive lung diseases. Respir Res 18(1):123

    Article  PubMed  PubMed Central  Google Scholar 

  4. Tashiro J, Rubio GA, Limper AH et al (2017) Exploring animal models that resemble idiopathic pulmonary fibrosis. Front Med (Lausanne) 4:118

    Article  PubMed  Google Scholar 

  5. Ahangari F, Becker C, Foster DG et al (2022) Saracatinib, a selective Src kinase inhibitor, blocks fibrotic responses in preclinical models of pulmonary fibrosis. Am J Respir Crit Care Med 206(12):1463–1479

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The scientific content described in this correspondence is solely the author’s responsibility and does not necessarily represent the official view of the NIH. The authors would like to thank Brian Egan for scientific editing.

Funding

IKS is supported in part by the National Institutes of Health NIH R01HL142543, the National Institute of General Medical Sciences P20 GM103418, as well as the University of Kansas Medical Center, School of Medicine, Internal Medicine Start-Up Funds. SMM is supported by the National Institutes of Health NIH P20GM130423.

Author information

Authors and Affiliations

Authors

Contributions

IKS and SMM drafted the correspondence article.

Corresponding author

Correspondence to Isaac Kirubakaran Sundar.

Ethics declarations

Conflict of interest

The authors have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sundar, I.K., Matson, S.M. Missing Nuts and Bolts: Translating Pulmonary Fibrosis from Preclinical Murine Models to Human Clinical Trials. Lung 202, 221–222 (2024). https://doi.org/10.1007/s00408-024-00676-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00408-024-00676-4

Navigation