Further study on a 95% EtOH extract of the red mold rice fermented with the mutant of the fungus Monascus sp. led to the isolation of one new natural pyranoid derivative, namely monascuslactone (1), together with three known compounds. The structure of the new compound was determined as (4S*,6S*)-4-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-one. The known compounds were identified as monascin (2), ankaflavin (3), and methyl N-methyl anthranylate (4). Their structures were elucidated by 1D and 2D NMR spectroscopy together with HR-ESI-MS analysis, and comparison of the spectroscopic data with those reported for structurally related compounds.
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Acknowledgment
This work was kindly supported by grants from the Ministry of Science and Technology, R.O.C. (MOST-108-2320-B-080-002-, MOST-109- 2622-E-080-001-, MOST-110-2320-B-080-001-, and NSTC-111-2320-B-030-010-MY3). The authors thank Senior Technician Mrs. Chyi Jia Wang of the Center for Resources, Research, and Development (CRRD) of Kaohsiung Medical University for measuring the 2D NMR data.
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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2024, pp. 27–29.
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Wu, MD., Chen, MH., Chen, JJ. et al. Constituents Isolated from the Fungus Monascus sp.. Chem Nat Compd 60, 30–33 (2024). https://doi.org/10.1007/s10600-024-04245-2
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DOI: https://doi.org/10.1007/s10600-024-04245-2