In order to explore new gallic acid derivatives with high antibacterial activity, we synthesize a series of new 1-(3,4,5-trihydroxybenzoyl)-4-(substituted benzoyl)thiosemicarbazide and evaluate their activities against Vibrio harveyi, Vibrio cholerae, Vibrio parahaemolyticus, and Vibrio vulnificus in vitro. Through the experiments, we found that compound 7d has the best inhibitory activity against V. harveyi and V. cholerae, the minimum inhibitory concentration (MIC) values were 0.0078 mg/mL and 0.0156 mg/mL; compound 7h has the best inhibitory activity against V. parahaemolyticus and V. vulnificus, with MIC values of 0.0313 mg/mL and 0.0625 mg/mL.
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This manuscript was funded by the Postgraduate Research and Practice Innovation Program of Jiangsu Province (KYCX2022-079), a Project Funded by the Priority Academic Program Development of two Higher Education Institutions (PAPD), the Student Innovation and Entrepreneurship Program (SY202211641640004, Z202211641640006) and the North Jiangsu Science and technology development plan (enriching the people and strengthening the country with science and technology) project (SZ-LYG202129).
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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2024, pp. 94–97.
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Gao, Tt., Liang, Xw., Qiu, M. et al. Synthesis and Anti-VIBRIO Activity of Gallic Acid Derivatives Containing Thiosemicarbazide. Chem Nat Compd 60, 110–114 (2024). https://doi.org/10.1007/s10600-024-04264-z
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DOI: https://doi.org/10.1007/s10600-024-04264-z