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Commikuanoid D: A New Potent Carbonic Anhydrase-II Inhibitor from the Resin of Commiphora kua

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Chemistry of Natural Compounds Aims and scope

A new compound, commikuanoid D, was isolated from the ethyl acetate fraction of Commiphora kua resin. The structure was unambiguously elucidated on the basis of complete spectroscopic analysis. Furthermore, the compound displayed potent carbonic anhydrase II inhibition with IC50 of 17.4 ± 0.32 μM. On the other hand, the molecular docking reflected that the acetyl group of the molecule specifically binds with the Zn ion at the active site of CA-II, and the OH group of the compound mediated hydrogen bonding with Gln92, thus blocking the enzyme activity with a good binding score (≥ 7 kcal/mol).

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Acknowledgment

The authors are thankful to The Oman Research Council (TRC) for their support through the Research Grant Program (BFP/RGP/CBS/21/002). The authors are also grateful to Mr. Saif Al Hatmi, Oman Botanic Garden, Oman, for the collection of C. kua resin.

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Authors and Affiliations

  1. Natural & Medical Sciences Research Center, University of Nizwa, Postal Code 616, Birkat Al Mauz, P.O Box 33, Nizwa, Sultanate of Oman

    Najeeb Ur Rehman, Sobia Ahsan Halim, Ajmal Khan, Majid Khan & Ahmed Al-Harrasi

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  1. Najeeb Ur Rehman
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  2. Sobia Ahsan Halim
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  3. Ajmal Khan
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  4. Majid Khan
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  5. Ahmed Al-Harrasi
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Correspondence to Ahmed Al-Harrasi.

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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2024, pp. 65–68.

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Rehman, N.U., Halim, S.A., Khan, A. et al. Commikuanoid D: A New Potent Carbonic Anhydrase-II Inhibitor from the Resin of Commiphora kua. Chem Nat Compd 60, 75–79 (2024). https://doi.org/10.1007/s10600-024-04258-x

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  • DOI: https://doi.org/10.1007/s10600-024-04258-x

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