Immunology of Kidney Disease

Orestes Foresto-Neto; Luísa Menezes-Silva; Jefferson Antônio Leite; Magaiver Andrade-Silva; Niels Olsen Saraiva Câmara

doi:10.1146/annurev-immunol-090122-045843

Annual Review of Immunology

Review Article

Immunology of Kidney Disease

Orestes Foresto-Neto^1,2, Luísa Menezes-Silva¹, Jefferson Antônio Leite¹, Magaiver Andrade-Silva^1,2, and Niels Olsen Saraiva Câmara^1,2
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Affiliations: ¹Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; email: [email protected], [email protected] ²Nephrology Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil ^*,†These authors contributed equally to this article
Vol. 42 https://doi.org/10.1146/annurev-immunol-090122-045843
© Annual Reviews

Abstract

The immune system and the kidneys are closely related. Immune components mediate acute kidney disease and are crucial to the progression of chronic kidney disease. Beyond its pathogenic functions, the immune system supports immunological homeostasis in healthy kidneys. The kidneys help maintain immune equilibrium by removing metabolic waste products and toxins, thereby limiting local and systemic inflammation. In this review, we describe the close relationship between the immune system and the kidneys. We discuss how the imbalance in the immune response can be deleterious to the kidneys and how immunomodulation can be important in preventing end-stage renal disease. In addition, recent tools such as in silico platforms and kidney organoids can help unveil the relationship between immune cells and kidney homeostasis.

Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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