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Altered cerebellar volumes and intrinsic cerebellar networks in patients with transient global amnesia

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Abstract

This study aimed to investigate the differences in cerebellar volumes and intrinsic cerebellar networks between patients with transient global amnesia (TGA) and healthy controls. We retrospectively enrolled patients with TGA and age- and sex-matched healthy controls. We used three-dimensional T1-weighted imaging at the time of TGA diagnosis to obtain cerebellar volumes, and the intrinsic cerebellar network was calculated by applying graph theory based on cerebellar volumes. The nodes were defined as individual cerebellar volumes, and edges as partial correlations, controlling for the effects of age and sex. The cerebellar volumes and intrinsic cerebellar networks were compared between the two groups. We enrolled 44 patients with TGA and 47 healthy controls. The volume of the left cerebellar white matter in patients with TGA was significantly lower than that in healthy controls (1.0328 vs. 1.0753%, p = 0.0094). In addition, there were significant differences in intrinsic cerebellar networks between the two groups. The small-worldness index in patients with TGA was higher than that in the healthy controls (0.951 vs. 0.880, p = 0.038). In the correlation analysis, the volumes of the right cerebellar cortex and lobules VIIIB were significantly correlated with age in patients with TGA (r = -0.323, p = 0.033; r = -0.313, p = 0.038, respectively). Patients with TGA exhibit alterations in cerebellar volumes and intrinsic cerebellar networks compared with healthy controls. These findings may contribute to a better understanding of the pathophysiology of the TGA.

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Data availability

Data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

This work was supported by the Ministry of Science and ICT of the Republic of Korea (NRF-2021R1F1A1049605).

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  1. Dong Ah Lee, Ho-Joon Lee these authors equally contributed to this work.

Authors and Affiliations

  1. Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Haeundae-Ro 875, Haeundae-Gu, Busan, Republic of Korea

    Dong Ah Lee & Kang Min Park

  2. Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea

    Ho-Joon Lee

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Author contributions included conception and study design (KMP), data collection or acquisition (DAL and HL), statistical analysis (KMP), interpretation of results (All authors), drafting the manuscript work or revising it critically for important intellectual content (All authors) and approval of final version to be published and agreement to be accountable for the integrity and accuracy of all aspects of the work (All authors).

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Correspondence to Kang Min Park.

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This protocal was approved and carried out in accordance with the recommendation of the local Institutional Review Board (Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea).

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Lee, D.A., Lee, HJ. & Park, K.M. Altered cerebellar volumes and intrinsic cerebellar networks in patients with transient global amnesia. Brain Imaging and Behavior (2023). https://doi.org/10.1007/s11682-023-00833-y

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