With the aims of screening more antibacterial activity metabolites, in this study, two new (1 and 2), together with five known (3–7) isoquinolines were isolated from the cigar tobacco-derived endophytic fungi Aspergillus puniceus. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. The new compounds were evaluated for antibacterial activities against Pseudomonas syringae (the main pathogenic sources of tobacco angular leaf spot disease), and compounds 1 and 2 exhibited inhibitory effects with MIC50 values of 8.5 and 5.4 μg/mL respectively. These rates are lower than that of positive control (agricultural streptomycin, with MIC50 of 2.2 μg/mL).
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References
A. Hagag, M. F. Abdelwahab, A. El-Kader, and M. A. Fouad, J. Appl. Microbiol., 132 (6), 4150 (2022).
S. S. El-Hawary, A. S. Moawad, H. S. Bahr, U. R. Abdelmohsen, and R. Mohammed, RSC. Adv., 10, 22058 (2020).
G. Y. Yang, J. M. Dai, Q. L. Mi, Z. J. Li, X. M. Li, J. D. Zhang, J. Wang, Y. K. Li, W. G. Wang, M. Zhou, and Q. F. Hu, Phytochemistry, 198, 113137 (2022).
J. M. Dai, Q. L. Mi. X. M. Li, D. Gang, G. Y. Yang, J. D. Zhang, J. Wang, Y. K. Li, H. Y. Yang, M. Dong, Z. J. Li, and Q. F. Hu, Phytochemistry, 205, 113485 (2023).
Y. N. Zhu, M. X. Liu, B. B. Cai, Y. Li, M. F. Li, H. S. Wang, M. Zhou, G. Y. Yang, Q. F. Hu, and Y. K. Li, Chem. Nat. Compd., 58, 712, (2022).
M. F. Li, D. Xiao, L. C. Zhu, L. Liu, J. N. Zheng, X. J. Gu, Y. N. Zhu, J. Xie, X. Wang, J. M. Dai, Q. L. Mi, Y. K. Yang, Q. F. Hu, Y. K. Li, and J. Q. Shi, Chem. Nat. Compd., 58, 1093 (2012).
J. M. Dai, L. C. Zhu, D. Xiao, J. Xie, X. Wang, Q. L. Mi, J. Q. Shi, G. Y. Yin, Y. K. Yang, G. Y. Yang, Q. F. Hu, and W. Kai, Chem. Nat. Compd., 58, 1005 (2022).
B. Debnath, W. S. Singh, M. Das, S. Goswami, M. K. Singh, D. Maiti, and K. Manna, Mater. Today Chem., 9, 56 (2018).
P. Yadav and K. Shah, Bioorg. Chem., 109, 104639 (2021).
G. Prabal and S. K. Gopinatha, Mini-Rev. Med. Chem., 10, 568 (2010).
Q. Li, C. M. Chen, Y. He, M. S. Wei, L. Cheng, X. Kang, J. P. Wang, X. C. Hao, H. C. Zhu, and Y. H Zhang, Phytochemistry, 169, 112177 (2020).
Acknowledgment
This project was supported by the Foundation of the China Tobacco Monopoly Bureau Grants and Yunnan Provincial Tobacco Monopoly Bureau Grants (110202103018, 2022530000241004), the National Natural Science Foundation of China (No. 32260111), and the Foundation of Yunnan Innovative Research Team (2019HC020).
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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2023, pp. 963–966.
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Chen, MS., Qiu, WY., Lin, ZL. et al. Two New Isoquinolines from Cigar Tobacco-Derived Endophytic Fungi Aspergillus puniceus and Their Antibacterial Activity. Chem Nat Compd 59, 1142–1146 (2023). https://doi.org/10.1007/s10600-023-04212-3
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DOI: https://doi.org/10.1007/s10600-023-04212-3