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Synthesis and Antimicrobial Activity of Phthalide Derivatives of Cytisine, Anabasine, and Salsoline

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Chemistry of Natural Compounds Aims and scope

Aminophthalide derivatives of cytisine, anabasine, and salsoline were obtained in high yields via condensation of the alkaloids with o-formylbenzoic acid. Their structures were proven using 1H and 13C NMR spectroscopy and data from 2D COSY 1H–1H and HMQC 1H–13C spectra. Studies of their antimicrobial activity showed moderate antimicrobial activity of 3-(N-cytisin-1-yl)isobenzofuran-1(3H)-one and 3-(N-salsolin-1-yl)isobenzofuran-1(3H)-one against Gram-positive test strain Staphylococcus aureus ATCC 6538 and Gram-negative test strain Escherichia coli ATCC 25922.

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Acknowledgment

The work was financially supported by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan (PTsF No. BR05236438).

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Authors and Affiliations

  1. Institute of Organic Synthesis and Coal Chemistry, Republic of Kazakhstan, 1 Alikhanov St, 100008, Karaganda, Kazakhstan

    O. A. Nurkenov, S. D. Fazylov, Zh. S. Nurmaganbetov, Z. M. Muldakhmetov & A. M. Gazaliev

  2. Karaganda Medical University, 40 Gogol St, 100012, Karaganda, Kazakhstan

    Zh. S. Nurmaganbetov & R. B. Seidakhmetova

  3. Sh. Ualikhanov Kokshetau University, 76 Abay St, 020000, Kokshetau, Kazakhstan

    T. M. Seilkhanov

Authors
  1. O. A. Nurkenov
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  2. S. D. Fazylov
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  3. Zh. S. Nurmaganbetov
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  4. T. M. Seilkhanov
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  5. R. B. Seidakhmetova
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  6. Z. M. Muldakhmetov
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  7. A. M. Gazaliev
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Correspondence to S. D. Fazylov.

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Translated from Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2023, pp. 967–970.

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Nurkenov, O.A., Fazylov, S.D., Nurmaganbetov, Z.S. et al. Synthesis and Antimicrobial Activity of Phthalide Derivatives of Cytisine, Anabasine, and Salsoline. Chem Nat Compd 59, 1147–1150 (2023). https://doi.org/10.1007/s10600-023-04213-2

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  • DOI: https://doi.org/10.1007/s10600-023-04213-2

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