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The diagnostic accuracy of endoscopic ultrasound-shear wave elastography in multiple pancreatic regions for chronic pancreatitis based on the Rosemont criteria

  • Original Article–Gastroenterology
  • Published:
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Abstract

Purpose

Although endoscopic ultrasound (EUS) has been widely used for diagnosing chronic pancreatitis (CP), the assessment of fibrosis using the Rosemont criteria (RC) is generally subjective. Shear wave elastography using EUS (EUS-SWE) has been advocated as an objective approach to evaluating pancreatic fibrosis; however, it is unknown which pancreatic region should be selected for measurement. This study aims to compare the diagnostic accuracy in diagnosing CP by measurement site.

Methods

Fifty patients with CP or suspected CP who underwent EUS-SWE were retrospectively analyzed. As per the RC, they were classified into two groups: CP and non-CP. Pancreatic stiffness was evaluated by measuring the velocities of the shear wave (Vs) in addition to determining the relevant cutoff value of Vs for diagnosing CP. The correlation between Vs and RC, and the RC factors affecting pancreatic stiffness were evaluated.

Results

In the CP group, the Vs were notably higher in all regions (P < 0.001). The Vs for diagnostic accuracy of CP were highest in the body [area under the curve (AUC): 0.87]. A significant correlation was seen between the number of RC and Vs in all regions, with the correlation coefficient being highest in the pancreatic body (rs = 0.55). Multivariate analysis revealed that lobularity with honeycombing was an independent factor for pancreatic stiffness (P = 0.02).

Conclusion

The pancreatic body is a suitable region for assessing pancreatic stiffness using EUS-SWE. Additionally, quantifying Vs is a valuable objective indicator for diagnosing CP.

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Funding

All authors disclosed no financial relationships relevant to this study.

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Authors and Affiliations

  1. Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga, 520-2192, Japan

    Shuhei Shintani, Osamu Inatomi, Kosuke Hiroe, Atsushi Nishida & Akira Andoh

  2. Department of Endoscopy, Shiga University of Medical Science, Otsu, Japan

    Hidenori Kimura

  3. Department of Radiology, Shiga University of Medical Science, Otsu, Japan

    Yuki Tomozawa, Akitoshi Inoue & Yoshiyuki Watanabe

  4. Department of General Medicine, Shiga University of Medical Science, Otsu, Japan

    Yoshihisa Tsuji

Authors
  1. Shuhei Shintani
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  2. Osamu Inatomi
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  3. Kosuke Hiroe
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  4. Yuki Tomozawa
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  5. Akitoshi Inoue
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  6. Hidenori Kimura
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  7. Atsushi Nishida
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  8. Yoshihisa Tsuji
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  9. Yoshiyuki Watanabe
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  10. Akira Andoh
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Corresponding author

Correspondence to Osamu Inatomi.

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The authors declare that they have no conflicts of interest.

Ethical approval and consent to participate

The study was conducted in accordance with the Declaration of Helsinki, and it received approval from the ethics committee of Shiga University of Medical Sciences and conformed to its guidelines (Approval No.: R2021-143).

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Shintani, S., Inatomi, O., Hiroe, K. et al. The diagnostic accuracy of endoscopic ultrasound-shear wave elastography in multiple pancreatic regions for chronic pancreatitis based on the Rosemont criteria. J Med Ultrasonics 50, 485–492 (2023). https://doi.org/10.1007/s10396-023-01350-7

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  • DOI: https://doi.org/10.1007/s10396-023-01350-7

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