Journal of Biological Chemistry
Volume 299, Issue 7, July 2023, 104879
Research ArticleThe role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction
Under a Creative Commons license
open access
Keywords
manganese
microglia
inflammation
LRRK2
G2019S
NLRP3 inflammasome
RAB10
autophagy
lysosome
Abbreviations
aCSF
artificial cerebrospinal fluid
AD
Alzheimer's disease
ATG5
autophagy-related 5
Bax
Bcl-2 associated X protein
Bcl-2
B-cell lymphoma 2
CASP1
caspase 1
CASP3
caspase 3
cDNA
complementary DNA
CM
conditioned media
CTSB
cathepsin B
DN-RAB10
dominant negative RAB10
ELISA
enzyme-linked immunosorbent assay
FO
familiar object
G2019S
glycine to serine substitution at amino acid 2019
GAPDH
glyceraldehyde 3-phosphate dehydrogenase
HMC3
human microglial cells 3
HPLC-ECD
high-performance liquid chromatography with electrochemical detector
HRP
horse-radish peroxidase
I2020T
isoleucine to threonine substitution at amino acid 2020
IHC
immunohistochemistry
IL-1β
interleukin 1 beta
KCl
potassium chloride
LAMP1
lysosomal-associated membrane protein 1
LRRK2
leucine-rich repeat kinase 2
MAPK
mitogen-activated protein kinase
NLRP3
nucleotide-binding domain, leucine-rich repeat-containing protein 3 or NOD-like receptor family, pyrin domain-containing 3
NO
novel object
PD
Parkinson's disease
PBS
phosphate-buffered saline
PLA
proximity ligation assay
R1441C/G/H
arginine to cysteine/glycine/histidine substitution at amino acid 1441
RAB10
Ras-related protein Rab10
TH
tyrosine hydroxylase
TNF-alpha
tumor necrosis factor-alpha
WT
wild type
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© 2023 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.