Meta-analysis of genome-wide association studies of spontaneous coronary artery dissection (SCAD), an important cause of myocardial infarction, identified 11 risk loci that involve genes related to artery integrity and tissue-mediated coagulation. Evidence supports SCAD as a genetically distinct condition from atherosclerotic coronary artery disease.
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References
Hayes, S. N. et al. Spontaneous coronary artery dissection: JACC state-of-the-art review. J. Am. Coll. Cardiol. 76, 961–984 (2020). A review article that describes the clinical presentation of SCAD.
Margaritis, M. et al. Vascular histopathology and connective tissue ultrastructure in spontaneous coronary artery dissection: pathophysiological and clinical implications. Cardiovasc. Res. 118, 1835–1848 (2022). A description of the histopathology of SCAD.
Carss, K. J. et al. Spontaneous coronary artery dissection: insights on rare genetic variation from genome sequencing. Circ. Genom. Precis. Med. 13, e003030 (2020). A sequencing study that investigates the frequency of potential causal rare genetic variants in SCAD.
Amrani-Midoun, A., Adlam, D. & Bouatia-Naji, N. Recent advances on the genetics of spontaneous coronary artery dissection. Circ. Genom. Precis. Med. 14, e003393 (2021). A review article on the genetic basis of SCAD involving rare and common variants.
Saw, J. et al. Spontaneous coronary artery dissection: clinical outcomes and risk of recurrence. J. Am. Coll. Cardiol. 70, 1148–1158 (2017). An observational study that describes an association between hypertension and SCAD recurrence.
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This is a summary of: Adlam, D. et al. Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation. Nat. Genet. https://doi.org/10.1038/s41588-023-01410-1 (2023).
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Genetic and biological insights into spontaneous coronary artery dissection. Nat Genet 55, 912–913 (2023). https://doi.org/10.1038/s41588-023-01413-y
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DOI: https://doi.org/10.1038/s41588-023-01413-y
