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Women’s health

The flash dance of midlife: the Skylight 1 trial

Nature Medicine volume 29, pages 1324–1325 (2023)Cite this article

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For women who choose nonhormonal therapy for hot flashes, fezolinetant appears to be one of several modestly efficacious and safe options — but women want more.

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Fig. 1: Efficacy of treatments for menopause-related symptoms.

References

  1. Dominus, S. The New York Times Magazine https://go.nature.com/44DMJmp (1 February 2023).

  2. Rep. McKinley, D. B. [R-W.-1. H.R.8774 – 117th Congress (2021–2022): Menopause Research Act of 2022 (2022).

  3. Lederman, S. et al. Lancet 401, 1091–1102 (2023).

    Article  CAS  PubMed  Google Scholar 

  4. Williams, R. E. et al. Climacteric J. Int. Menopause Soc. 11, 32–43 (2008).

    Article  CAS  Google Scholar 

  5. Nappi, R. E. et al. Maturitas 167, 66–74 (2023).

    Article  PubMed  Google Scholar 

  6. Joffe, H. et al. JAMA Intern. Med. 174, 1058–1066 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Freeman, E. W. et al. JAMA 305, 267–274 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Beaudoin, F. L. et al. https://go.nature.com/3NUjcir (ICER, 2023).

  9. Johnson, K. A. et al. J. Clin. Endocrinol. Metab. https://doi.org/10.1210/clinem/dgad058 (2023).

    Article  PubMed  Google Scholar 

  10. Grand View Research. https://go.nature.com/3VKXHm3 (Cision PR Newswire, 2022).

  11. Davis, S. R. et al. Nat. Rev. Dis. Primer 1, 15004 (2015).

    Article  Google Scholar 

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Authors and Affiliations

  1. Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA

    Andrea LaCroix

  2. Departments of Medicine and Epidemiology and Community Health, University of Minnesota and Minneapolis VA Health Care System, Minneapolis, MN, USA

    Kristine Ensrud

Authors
  1. Andrea LaCroix
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  2. Kristine Ensrud
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Correspondence to Andrea LaCroix or Kristine Ensrud.

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The authors declare no competing interests.

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LaCroix, A., Ensrud, K. The flash dance of midlife: the Skylight 1 trial. Nat Med 29, 1324–1325 (2023). https://doi.org/10.1038/s41591-023-02359-8

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