In cancer, alternative polyadenylation has been shown to lead to altered 3′ UTRs with different regulatory potentials. A study now suggests a mechanism that leads to 3′ UTR lengthening and translational repression of a subset of metastasis-suppressing genes, revealing a new prospective therapeutic vulnerability.
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Watt, K., Postovit, LM. Tailoring 3′ UTRs alters metastatic potential. Nat Cell Biol 25, 805–807 (2023). https://doi.org/10.1038/s41556-023-01127-7
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DOI: https://doi.org/10.1038/s41556-023-01127-7
