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Quality control

A shared fate for nuclear and cytosolic inclusions

Nature Cell Biology volume 25, pages 629–630 (2023)Cite this article

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Coordination of protein quality control processes across organelles is poorly understood. A study now shows that the cytosolic juxtanuclear quality control (JUNQ) and intranuclear quality control (INQ) compartments face each other on opposite sides of the nuclear envelope before their vacuolar degradation, promoting proteostasis.

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Fig. 1: Model showing the vacuolar targeting and clearance of the intranuclear quality control (INQ) and cytoplasmic juxtanuclear quality control (JUNQ) compartments.

References

  1. Alberti, S. & Hyman, A. A. Nat. Rev. Mol. Cell Bio.l 22, 196–213 (2021).

    Article  CAS  Google Scholar 

  2. Sontag, E. M., Samant, R. S. & Frydman, J. Annu. Rev. Biochem. 86, 97–122 (2017).

    Article  CAS  PubMed  Google Scholar 

  3. Kumar, A., Mathew, V. & Stirling, P. C. J. Biol. Chem. 298, 102199 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Hipp, M. S., Kasturi, P. & Hartl, F. U. Nat. Rev. Mol. Cell Biol. 20, 421–435 (2019).

    Article  CAS  PubMed  Google Scholar 

  5. Sontag, E. M. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01128-6 (2023).

  6. Kvam, E. & Goldfarb, D. S. Autophagy 3, 85–92 (2007).

    Article  CAS  PubMed  Google Scholar 

  7. den Brave, F. et al. Cell Rep. 31, 107680 (2020).

    Article  Google Scholar 

  8. Kunadt, M. et al. Acta Neuropathol. 129, 695–713 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Li, Y. et al. J. Exp. Clin. Cancer Res. 38, 67 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Mediani, L. et al. EMBO J. 38, e101341 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Frottin, F. et al. Science 365, 342–347 (2019).

    Article  CAS  PubMed  Google Scholar 

  12. Pankiv, S. et al. J. Biol. Chem. 285, 5941–5953 (2010).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Biotechnology Center (BIOTEC), Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany

    Simon Alberti & Serena Carra

  2. Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

    Serena Carra

Authors
  1. Simon Alberti
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  2. Serena Carra
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Correspondence to Serena Carra.

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Competing interests

S.A. is a scientific advisor to Dewpoint Therapeutics. S.C. declares no competing interests.

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Alberti, S., Carra, S. A shared fate for nuclear and cytosolic inclusions. Nat Cell Biol 25, 629–630 (2023). https://doi.org/10.1038/s41556-023-01121-z

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