A study of drug-resistant lymphomas with hypermorphic mutations in PRC2 has identified a ‘methylation index’ by which cancer cells maintain optimal H3K27me3 levels for survival, emphasizing the importance of understanding how tumors adapt to changes in chromatin and to drug-resistance mutations.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Conway, E., Healy, E. & Bracken, A. P. Curr. Opin. Cell Biol. 37, 42–48 (2015).
Kwok et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01299-1 (2023).
Morin, R. D. et al. Nat. Genet. 42, 181–185 (2010).
Sneeringer, C. J. et al. Proc. Natl Acad. Sci. USA 107, 20980–20985 (2010).
Souroullas, G. P. et al. Nat. Med. 22, 632–640 (2016).
McCabe, M. T. et al. Nature 492, 108–112 (2012).
Harutyunyan, A. S. et al. Nat. Commun. 10, 1262 (2019).
Mohammad, F. et al. Nat. Med. 23, 483–492 (2017).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Reich, T.J., Lewis, P.W. A goldilocks amount of H3K27me3. Nat Chem Biol 19, 1046–1047 (2023). https://doi.org/10.1038/s41589-023-01295-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-023-01295-5
