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Extracellular vesicles

Niche tension controls exosome production

Nature Cell Biology volume 25, pages 377–378 (2023)Cite this article

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Extracellular matrix (ECM) stiffening is a hallmark of cancer aggressiveness. Diverse ECM environments can alter the number and cargo of small extracellular vesicles (sEVs). Wu et al. now delineate a pathway from ECM stiffness to FAK/PI3K/Akt signalling and Rab8-induced sEV secretion, promoting cancer growth.

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Fig. 1: ECM stiffening activates a FAK/PI3K/Akt signalling pathway to activate Rab8-mediated exosome secretion.

References

  1. Winkler, J., Abisoye-Ogunniyan, A., Metcalf, K. J. & Werb, Z. Nat. Commun. 11, 5120 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Sato, S. & Weaver, A. M. Essays Biochem. 62, 149–163 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Xiao, W. et al. Matrix Biol. Plus 14, 100111 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Liu, Z. et al. Biochem. Biophys. Rep. 31, 101299 (2022).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Wu, B. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01092-1 (2023).

    Article  PubMed  Google Scholar 

  6. Mitra, S. K. & Schlaepfer, D. D. Curr. Opin. Cell Biol. 18, 516–523 (2006).

    Article  CAS  PubMed  Google Scholar 

  7. Mouw, J. K. et al. Nat. Med. 20, 360–367 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Ostrowski, M. et al. Nat. Cell Biol. 12, 19–30 (2010).

    Article  CAS  PubMed  Google Scholar 

  9. Fan, S. J. et al. EMBO J. 39, e103009 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Walia, V. et al. Dev. Cell 50, 229–246 e227 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Gonzalez-King, H. et al. Stem Cells 35, 1747–1759 (2017).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA

    Toni Renee Dawson & Alissa Margaret Weaver

  2. Center for Extracellular Vesicle Research, Vanderbilt University School of Medicine, Nashville, TN, USA

    Toni Renee Dawson & Alissa Margaret Weaver

  3. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA

    Alissa Margaret Weaver

Authors
  1. Toni Renee Dawson
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  2. Alissa Margaret Weaver
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Correspondence to Alissa Margaret Weaver.

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The authors declare no competing interests.

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Dawson, T.R., Weaver, A.M. Niche tension controls exosome production. Nat Cell Biol 25, 377–378 (2023). https://doi.org/10.1038/s41556-023-01088-x

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