An ependymoma subtype is driven by fusion proteins related to the transcriptional regulator YAP1. Research now shows that localization of these fusion proteins within nuclear condensates is necessary and sufficient for tumour formation through the activation of various genetic and epigenetic oncogenic mechanisms.
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Dadras, M.S., Fine, H.A. Nuclear condensates in YAP1-driven ependymoma. Nat Cell Biol 25, 211–213 (2023). https://doi.org/10.1038/s41556-022-01081-w
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DOI: https://doi.org/10.1038/s41556-022-01081-w
