Alternative splicing of eukaryotic messenger RNA transcripts often leads to the production of several mature RNAs — including linear RNAs and circular RNAs (circRNAs) — from a single gene locus. The names given to circRNAs are often ambiguous and lack consistency across studies. This Comment calls on the community to embrace a common nomenclature for naming circRNAs to ensure clarity and reproducibility.
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References
Nilsen, T. W. & Graveley, B. R. Nature 463, 457–463 (2010).
Szabo, L. & Salzman, J. Nat. Rev. Genet. 17, 679–692 (2016).
Kristensen, L. S. et al. Nat. Rev. Genet. 20, 675–691 (2019).
Yang, L., Wilusz, J. E. & Chen, L. L. Annu. Rev. Cell Dev. Biol. 38, 263–289 (2022).
Liu, C. X. & Chen, L. L. Cell 185, 2016–2034 (2022).
Li, X. et al. Sci. China Life Sci. 64, 1795–1809 (2021).
Tay, M. L. & Pek, J. W. Curr. Biol. 27, 1062–1067 (2017).
Barrett, S. P., Parker, K. R., Horn, C., Mata, M. & Salzman, J. PLoS Genet. 13, e1007114 (2017).
Memczak, S. et al. Nature 495, 333–338 (2013).
Hansen, T. B. et al. Nature 495, 384–388 (2013).
Hansen, T. B. et al. EMBO J. 30, 4414–4422 (2011).
Li, S. et al. Nat. Methods 18, 51–59 (2021).
Xin, R. et al. Nat. Commun. 12, 266 (2021).
Seal, R. L. et al. EMBO J. 39, e103777 (2020).
Dong, R., Ma, X. K., Li, G. W. & Yang, L. Genom. Proteom. Bioinf. 16, 226–233 (2018).
Wu, W., Ji, P. & Zhao, F. Genome Biol. 21, 101 (2020).
Liu, M., Wang, Q., Shen, J., Yang, B. B. & Ding, X. RNA Biol. 16, 899–905 (2019).
Glazar, P., Papavasileiou, P. & Rajewsky, N. RNA 20, 1666–1670 (2014).
Morales, J. et al. Nature 604, 310–315 (2022).
Li, Z. et al. Nat. Struct. Mol. Biol. 22, 256–264 (2015).
Zhang, J. et al. Nat. Biotechnol. 39, 836–845 (2021).
Rahimi, K., Veno, M. T., Dupont, D. M. & Kjems, J. Nat. Commun. 12, 4825 (2021).
Bruford, E. A. et al. Leukemia 35, 3040–3043 (2021).
Guarnerio, J. et al. Cell 165, 289–302 (2016).
Lasda, E. & Parker, R. RNA 20, 1829–1842 (2014).
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J.E.W. is a consultant for Laronde. H.Y.C. is a co-founder of Orbital Therapeutics. The other authors declare no competing interests.
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Chen, LL., Bindereif, A., Bozzoni, I. et al. A guide to naming eukaryotic circular RNAs. Nat Cell Biol 25, 1–5 (2023). https://doi.org/10.1038/s41556-022-01066-9
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DOI: https://doi.org/10.1038/s41556-022-01066-9
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