Data and code availability
- •
The data supporting the findings of this study are available within the paper, its supplemental information and is deposited within publicly accessible repositories. The mass spectrometry proteomics data of chronologically aging SeMeCo, relevant to data shown in Figures 4, 6, S5, and S6, have been deposited to the ProteomeXchange Consortium via the PRIDE86 partner repository with the dataset identifier PRIDE: PXD036444. The mass spectrometry proteomics data of wild-type yeast supplemented with/out amino acids, relevant to data shown in Figure S3C, have been deposited to the Mendeley repository with dataset identifier Mendeley Data: https://doi.org/10.17632/sd8zthmrk4.1.
- •
Yeast gene functions and GO slim term mapper can be accessed at the Saccharomyces Genome Database (SGD: https://www.yeastgenome.org/). Protein sequence databases used for the identification and mapping of proteins from proteomics can be accessed via Uniprot:https://www.uniprot.org/ and KEGG: https://www.genome.jp/kegg/pathway.html. No custom software codes were generated as part of this study. All analyses conducted in R v4.1.3. used standard, publicly accessible packages obtained either through GitHub (https://github.com/), the Comprehensive R Archive Network (CRAN, https://cran.r-project.org/) or via Bioconductor (https://www.bioconductor.org/).
- •
Any additional information required to reanalyse the data reported in this paper is available from the lead contact upon request.