Design of supramolecular hybrid nanomaterials comprising peptide-based supramolecular nanofibers and in situ generated DNA nanoflowers through rolling circle amplification

Shintaro Sugiura; Yuki Shintani; Daisuke Mori; Sayuri L. Higashi; Aya Shibata; Yoshiaki Kitamura; Shin-ichiro Kawano; Koichiro M. Hirosawa; Kenichi G. N. Suzuki; Masato Ikeda

doi:10.1039/D2NR04556G

Design of supramolecular hybrid nanomaterials comprising peptide-based supramolecular nanofibers and in situ generated DNA nanoflowers through rolling circle amplification†

Shintaro Sugiura,^a Yuki Shintani,^b Daisuke Mori,^a Sayuri L. Higashi,

^b Aya Shibata,^a Yoshiaki Kitamura,

^ab Shin-ichiro Kawano,

^c Koichiro M. Hirosawa,^d Kenichi G. N. Suzuki

^d and Masato Ikeda

*^abde

Author affiliations

* Corresponding authors

^a Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
E-mail: m_ikeda@gifu-u.ac.jp

^b United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan

^c Department of Chemistry, Faculty of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan

^d Institute for Glyco-core Research (iGCORE), Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan

^e Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan

Abstract

The artificial construction of multicomponent supramolecular materials comprising plural supramolecular architectures that are assembled orthogonally from their constituent molecules has attracted growing attention. Here, we describe the design and development of multicomponent supramolecular materials by combining peptide-based self-assembled fibrous nanostructures with globular DNA nanoflowers constructed by the rolling circle amplification reaction. The orthogonally constructed architectures were dissected by fluorescence imaging using the selective fluorescence staining procedures adapted to this study. The present, unique hybrid materials developed by taking advantage of each supramolecular architecture based on their peptide and DNA functions may offer distinct opportunities to explore their bioapplications as a soft matrix.

Nanoscale

Design of supramolecular hybrid nanomaterials comprising peptide-based supramolecular nanofibers and in situ generated DNA nanoflowers through rolling circle amplification†

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Design of supramolecular hybrid nanomaterials comprising peptide-based supramolecular nanofibers and in situ generated DNA nanoflowers through rolling circle amplification

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