Metabolic rewiring of activated macrophages promotes glycolysis and contributes to bacterial killing. A new study shows that reactive nitrogen species, released during macrophage activation, induce a profound inhibitory signal that facilitates metabolic reprogramming by modification of lipoate.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
O’Neill, L. A. & Pearce, E. J. J. Exp. Med. 213, 15–23 (2016).
McGettrick, A. F. & O’Neill, L. A. J. Cell Metab. 32, 524–536 (2020).
Seim, G. L. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-022-01153-w (2022).
Solmonson, A. & DeBerardinis, R. J. J. Biol. Chem. 293, 7522–7530 (2018).
Solmonson, A. et al. Nature 604, 349–353 (2022).
Cao, X., Zhu, L., Song, X., Hu, Z. & Cronan, J. E. Proc. Natl Acad. Sci. USA 115, E7063–E7072 (2018).
Bailey, P. S. J. et al. Nat. Commun. 11, 4046 (2020).
Mathias, R. A. et al. Cell 159, 1615–1625 (2014).
Seim, G. L. et al. Nat. Metab. 1, 731–742 (2019).
Clementi, E., Brown, G. C., Feelisch, M. & Moncada, S. Proc. Natl Acad. Sci. USA 95, 7631–7636 (1998).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Nathan, J.A. Nitrosylation rewires metabolism. Nat Chem Biol 19, 253–254 (2023). https://doi.org/10.1038/s41589-022-01169-2
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-022-01169-2
