Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review Article
  • Published:

Odour hedonics and the ubiquitous appeal of vanilla

Abstract

Our food choices and consumption behaviours are often influenced by odour hedonics, especially in the case of those orthonasally experienced aromas (that is, those odours that are food-related). The origins of odour hedonics remain one of the most intriguing puzzles in olfactory science and, over the years, several fundamentally different accounts have been put forwards to try and explain the varying hedonic responses that people have to a wide range of odorants. Associative learning, innate and molecular accounts of odour pleasantness have all been suggested. Here the origins of the hedonic response to vanilla, which is one of the most liked smells cross-culturally, are explored. The history of vanilla’s use in food and medicine is outlined, with a focus on its neurocognitive appeal. While vanilla is one of the most widely liked aromas, it is also rated as smelling sweet to most people. Food scientists are becoming increasingly interested in the possibility that such ‘sweet smells’ could be used to help maintain the sweetness of commercial food products while, at the same time, reducing the use of calorific sweeteners. Such an approach is likely to be facilitated by the low cost of artificial vanilla flavouring (when compared with the high and fluctuating price of natural vanilla pods).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. McGann, J. P. Poor human olfaction is a 19th-century myth. Science 356, eaam7263 (2017).

    PubMed  PubMed Central  Google Scholar 

  2. Spence, C. Using ambient scent to enhance well-being in the multisensory built environment. Front. Psychol. 11, 598859 (2020).

    PubMed  PubMed Central  Google Scholar 

  3. Spence, C. Sensehacking: How to Use the Power of Your Senses for Happier, Heathier Living (Viking Penguin, 2021).

  4. Croy, I., Bojanowski, V. & Hummel, T. Men without a sense of smell exhibit a strongly reduced number of sexual relationships, women exhibit reduced partnership security—a reanalysis of previously published data. Biol. Psychol. 92, 292–294 (2013).

    PubMed  Google Scholar 

  5. Spence, C. The scent of attraction & the smell of success: crossmodal influences on person perception. Cogn. Res. 6, 46 (2021).

    Google Scholar 

  6. Croy, I., Negioas, S., Novakova, L., Landin, B. N. & Hummel, T. Learning about the functions of the olfactory system from people without a sense of smell. PLoS ONE 7, e33365 (2012).

    ADS  CAS  PubMed  PubMed Central  Google Scholar 

  7. Sharma, A. et al. Sense of smell: structural, functional, mechanistic advancements and challenges in human olfactory research. Curr. Neuropharmacol. 17, 891–911 (2019).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Spence, C. Leading the consumer by the nose: on the commercialization of olfactory-design for the food and beverage sector. Flavour 4, 31 (2015).

    Google Scholar 

  9. Spence, C. Enhancing the experience of food and drink via neuroscience-inspired olfactory design. Senses Soc. 12, 209–221 (2017).

    Google Scholar 

  10. Hutmacher, F. Why is there so much more research on vision than on any other sensory modality? Front. Psychol. 10, 2246 (2019).

    PubMed  PubMed Central  Google Scholar 

  11. Spence, C. On the psychological impact of food colour. Flavour 4, 21 (2015).

    Google Scholar 

  12. Spence, C. & Levitan, C. A. Explaining crossmodal correspondences between colours and tastes. i-Perception https://doi.org/10.1177/20416695211018223 (2021).

  13. Herz, R. The Scent of Desire: Discovering Our Enigmatic Sense of Smell (William Morrow, 2007).

  14. Khan, R. M. et al. Predicting odor pleasantness from odorant structure pleasantness as a reflection of the physical world. J. Neurosci. 27, 10015–10023 (2007).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Yeshurun, Y. & Sobel, N. An odor is not worth a thousand words: from multidimensional odors to unidimensional odor objects. Annu. Rev. Psychol. 61, 219–241 (2010).

    PubMed  Google Scholar 

  16. Soudry, Y., Lemogne, C., Malinvaud, D., Consoli, S. M. & Bonfils, P. Olfactory system and emotion: common substrates. Euro. Ann. Otorhinolaryngol. 128, 18–23 (2011).

    CAS  Google Scholar 

  17. Stevenson, R. J. & Boakes, R. A. in The Handbook of Multisensory Processing (eds Calvert, G. A. et al.) 69–83 (MIT Press, 2004).

  18. Aikman, L. Perfume, the business of illusion. Natl Geogr. 99, 531–550 (1951).

    Google Scholar 

  19. Moran, T. Ah, the aroma of a just-baked sedan. The New York Times (14 May 2000).

  20. Moran, T. Sniffing car parts: yes, the job stinks. The New York Times (14 May 2000).

  21. Arshamian, A. et al. A mammalian blood odor component serves as an approach-avoidance cue across phylum border—from flies to humans. Sci. Rep. 7, 13635 (2017).

    ADS  PubMed  PubMed Central  Google Scholar 

  22. Mandairon, N., Poncelet, J., Bensafi, M. & Didier, A. Humans and mice express similar olfactory preferences. PLoS ONE 4, 4209 (2009).

    ADS  Google Scholar 

  23. Spence, C. Factors affecting odour-induced taste enhancement. Food Qual. Pref. 96, 104393 (2022).

    Google Scholar 

  24. Joussain, P., Chakirian, A., Kermen, F., Rouby, C. & Bensafi, M. Physicochemical influence on odor hedonics: where does it occur first? Commun. Integr. Biol. 4, 563–565 (2011).

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Caballero, B. The global epidemic of obesity: an overview. Epidemiol. Rev. 29, 1–5 (2007).

    PubMed  Google Scholar 

  26. Arshamian, A. et al. The perception of odor pleasantness is shared across cultures. Curr. Biol. 32, P2061–P2066.E3 (2022).

    Google Scholar 

  27. Rain, P. Vanilla: The Cultural History of the World’s Favorite Flavor and Fragrance (Jeremy P. Tarcher, 2004).

  28. Kaiser, R. Meaningful Scents Around the World: Olfactory, Chemical, Biological, and Cultural Considerations (Wiley, 2006).

  29. Pangborn, R. M., Guinard, J.-X. & Davis, R. G. Regional aroma preferences. Food Qual. Pref. 1, 11–19 (1988).

    Google Scholar 

  30. Ayabe-Kanamura, S. et al. Differences in perception of everyday odors: a Japanese–German cross-cultural study. Chem. Senses 23, 31–38 (1998).

    CAS  PubMed  Google Scholar 

  31. Schleidt, M., Neumann, P. & Morishita, H. Pleasure and disgust: memories and associations of pleasant and unpleasant odours in Germany and Japan. Chem. Senses 13, 279–293 (1988).

    Google Scholar 

  32. Seo, H.-S., Buschhüter, D. & Hummel, T. Odor attributes change in relation to the time of the year. Cinnamon odor is more familiar and pleasant during Christmas season than summertime. Appetite 53, 222–225 (2009).

    PubMed  Google Scholar 

  33. Wada, Y. et al. Infant visual preference for fruit enhanced by congruent in-season odor. Appetite 58, 1070–1075 (2012).

    PubMed  Google Scholar 

  34. De Araujo, I. E., Rolls, E. T., Velazco, M. I., Margot, C. & Cayeux, I. Cognitive modulation of olfactory processing. Neuron 46, 671–679 (2005).

    PubMed  Google Scholar 

  35. Herz, R. S. & von Clef, J. The influence of verbal labelling on the perception of odors: evidence for olfactory illusions? Perception 30, 381–391 (2001).

    CAS  PubMed  Google Scholar 

  36. Bensafi, M., Rinck, F., Schaal, B. & Rouby, C. Verbal cues modulate hedonic perception of odors in 5-year-old children as well as in adults. Chem. Senses 32, 855–862 (2007).

    PubMed  Google Scholar 

  37. Djordjevic, J. et al. A rose by any other name: would it smell as sweet? J. Neurophysiol. 99, 386–393 (2008).

    PubMed  Google Scholar 

  38. Cain, W. S. in Preference Behavior and Chemoreception (ed. Kroeze, J. H. A.) 303–315 (IRL, 1979).

  39. Poncelet, J. et al. Semantic knowledge influences prewired hedonic responses to odors. PLoS ONE 5, 13878 (2010).

    ADS  Google Scholar 

  40. Rouby, C., Pouliot, S. & Bensafi, M. Odor hedonics and their modulators. Food Qual. Prefer. 8, 545–549 (2009).

    Google Scholar 

  41. Distel, H. et al. Perception of everyday odors – correlation between intensity, familiarity and strength of hedonic judgment. Chem. Senses 24, 191–199 (1999).

    CAS  PubMed  Google Scholar 

  42. Faas, M. M., Melgert, B. N. & de Vos, P. A brief review on how pregnancy and sex hormones interfere with taste and food intake. Chemosens. Percept. 3, 51–56 (2010).

    PubMed  Google Scholar 

  43. Kringelbach, M. L., O’Doherty, J., Rolls, E. T. & Andrews, C. Sensory-specific satiety for the flavour of food is represented in the orbitofrontal cortex. NeuroImage 11, S767 (2000).

    Google Scholar 

  44. Rolls, E. T. & Rolls, J. H. Olfactory sensory-specific satiety in humans. Physiol. Behav. 61, 461–473 (1997).

    CAS  PubMed  Google Scholar 

  45. Brand, G. & Millot, J.-L. Sex differences in human olfaction: between evidence and enigma. Q. J. Exp. Psychol. 54B, 259–270 (2001).

    Google Scholar 

  46. Spence, C. Do men and women really live in different taste worlds? Food Qual. Prefer. 73, 38–45 (2019).

    Google Scholar 

  47. Joussain, P., Thevenet, M., Rouby, C. & Bensafi, M. Effect of aging on hedonic appreciation of pleasant and unpleasant odors. PLoS ONE 8, e61376 (2013).

    ADS  CAS  PubMed  PubMed Central  Google Scholar 

  48. Zhao, J. B. et al. The chemosensory pleasure scale: a new assessment for measuring hedonic smell and taste capacities. Chem. Senses 44, 457–464 (2019).

    PubMed  Google Scholar 

  49. De Wijk, R. A. & Zijlstra, S. M. Differential effects of exposure to ambient vanilla and citrus aromas on mood, arousal and food choice. Flavour 1, 24 (2012).

    Google Scholar 

  50. Saint-Bauzel, R. & Fointiat, V. The sweet smell of the requester: vanilla, camphor, and foot-in-the-door. Soc. Behav. Personal. 40, 369–374 (2012).

    Google Scholar 

  51. Demetros, V. A. M. The sweet smell of success. The Crafts Report https://go.nature.com/3SVA9Iy (1997).

  52. Hultén, B. Sensory cues and shoppers’ touching behaviour: the case of IKEA. Int. J. Retail Distrib. Manage. 40, 273–289 (2012).

    Google Scholar 

  53. Fetterman, J. & O’Donell, J. Just browsing the mall? That’s what you think. USA Today http://usatoday30.usatoday.com/money/industries/retail/2006-09-01-retail-cover-usat_x.htm (2006).

  54. Trivedi, B. Recruiting smell for the hard sell. New Sci. 2582, 36–39 (2006).

    Google Scholar 

  55. Hoppough, S. What’s that smell? Forbes https://www.forbes.com/forbes/2006/1002/076.html#3ef667ec5377 (2006).

  56. Herz, R. S. in Sensory Marketing: Research on the Sensuality of Products (ed. Krishna, A.) 87–107 (Routledge, 2010).

  57. Abreu-Runkel, R. Vanilla: A Global History (Reaktion Books, 2020).

  58. Ecott, T. Vanilla: Travels in Search of a Luscious Substance (Michael Joseph, 2004).

  59. Youssef, J. & Spence, C. Introducing diners to the range of experiences in creative Mexican cuisine, including the consumption of insects. Int. J. Gastron. Food Sci. 25, 100371 (2021).

    Google Scholar 

  60. Sethi, S. The bittersweet story of vanilla. Smithsonian Magazine https://www.smithsonianmag.com/science-nature/bittersweet-story-vanilla-180962757/ (2017).

  61. Gamboa-Gaitán, M. A. & Otero-Ospina, J. T. Colombian vanilla and its microbiota. III. Diversity and structure of the endophytic community. Acta Bot. Hung. 58, 241–256 (2016).

    Google Scholar 

  62. Hotta, M. et al. Useful Plants of the World (Heibonsha, 1989).

  63. Khoyrattya, S., Kodjac, H. & Verpoorte, R. Vanilla flavor production methods: a review. Ind. Crops Prod. 125, 433–442 (2018).

    Google Scholar 

  64. Nishi, T. Shokubutsu-no hanashi arekore 7. Puranta 64, 49–53 (1999).

    Google Scholar 

  65. Dignum, M. J. W., Kerler, J. & Verpoorte, R. Vanilla curing under laboratory conditions. Food Chem. 79, 165–171 (2002).

    CAS  Google Scholar 

  66. Walton, N. J., Mayer, M. J. & Narbad, A. Vanillin. Phytochemistry 63, 505–515 (2003).

    CAS  PubMed  Google Scholar 

  67. Soto-Arenas, M. A. & Cribb, P. A new infrageneric classification and synopsis of the genus Vanilla Plum. ex Mil. (Orchidaceae: Vanillinae). Lankesteriana 9, 355–398 (2010).

    Google Scholar 

  68. Bythrow, J. D. Vanilla as a medicinal plant. Semin. Integr. Med. 3, 129–131 (2005).

    Google Scholar 

  69. Bezerra, D. P., Soares, A. K. & de Sousa, D. P. Overview of the role of vanillin on redox status and cancer development. Oxid. Med. Cell Longev. 2016, 9734816 (2016).

    PubMed  PubMed Central  Google Scholar 

  70. Bezerra, D. P., Soares, A. K. & de Sousa, D. P. Therapeutic potential of vanillin and its main metabolites to regulate the inflammatory response and oxidative stress. Mini-Rev. Med. Chem. 19, 1681–1693 (2019).

    Google Scholar 

  71. Cheng, H. M. et al. Oral administration of vanillin improves imiquimod-induced psoriatic skin inflammation in mice. J. Agric. Food Chem. 65, 10233–10242 (2017).

    CAS  PubMed  Google Scholar 

  72. Fitzgerald, D. J. et al. Mode of antimicrobial action of vanillin against Escherichia coli, Lactobacillus plantarum and Listeria innocua. J. Appl. Microbiol. 97, 104–113 (2004).

    CAS  PubMed  Google Scholar 

  73. Fitzgerald, D. J., Stratford, M. & Narbad, A. Analysis of the inhibition of food spoilage yeasts by vanillin. Int. J. Food Microbiol. 86, 113–122 (2003).

    CAS  PubMed  Google Scholar 

  74. Cameron, K. M. in Handbook of Vanilla Science and Technology (eds Havkin-Frenkel, D. & Belangerp, F. C.) 243 (Wiley-Blackwell, 2011).

  75. Morini, G., Winnig, M., Vennegeerts, T., Borgonovo, G. & Bassoli, A. Vanillin activates human bitter taste receptors TAS2R14, TAS2R20, and TAS2R39. Front. Nutr. 8, 683627 (2021).

    PubMed  PubMed Central  Google Scholar 

  76. Draycott, J. in Smell and the Ancient Senses (ed. Bradley, M.) 60–73 (Routledge, 2015).

  77. Huber, B., Larsen, T., Spengler, R. N. & Boivin, N. How to use modern science to reconstruct ancient scents. Nat. Hum. Behav. https://doi.org/10.1038/s41562-022-01325-7 (2022).

  78. Classen, C., Howes, D. & Synnott, A. Aroma: The Cultural History of Smell (Routledge, 1994).

  79. Ranadive, A. S. in Handbook of Vanilla Science and Technology (eds Havkin-Frenkel, D. & Belanger, F. C.) 141–160 (Wiley-Blackwell, 2011).

  80. Diamond, A. Make Thomas Jefferson’s recipe for ice cream. The Smithsonian Magazine https://www.smithsonianmag.com/history/thomas-jefferson-ice-cream-recipe-180975200/ (2020).

  81. Kerr, J. History of chocolate. Field Museum http://archive.fieldmuseum.org/chocolate/history.html (2007).

  82. Newquist, H. P. The Book of Chocolate: The Amazing Story of the World’s Favorite Candy (Viking, 2017).

  83. Macinnis, P. Bittersweet: The Story of Sugar (Allen & Unwin, 2002).

  84. Mintz, S. Sweetness and Power: The Place of Sugar in Modern History (Penguin, 1985).

  85. Mintz, S. in The Taste Culture Reader: Experiencing Food and Drink (ed. Korsmeyer, C.) 110–122 (Berg, 2005).

  86. Spence, C. & Youssef, J. Personalized rock: a nostalgic fairground revival confection. Int. J. Gastron. Food Sci. 17, 100150 (2020).

    Google Scholar 

  87. Muchembled, R. Smells: A Cultural History of Odours in Early Modern Times (Polity, 2021).

  88. Ogawa, K., Tashima, A., Sadakata, M. & Morinaga, O. Appetite-enhancing effects of vanilla flavours such as vanillin. J. Nat. Med. 72, 798–802 (2018).

    CAS  PubMed  Google Scholar 

  89. Chemistry in its ElementVanillin (Royal Society of Chemistry, 2016); http://www.rsc.org/chemistryworld/podcast/CIIEcompounds/transcripts/vanillin.asp

  90. Dignum, M., Kerler, J. & Verpoorte, R. Vanilla production: technological, chemical and biosynthetic aspects. Food Res. Int. 17, 199–219 (2001).

    CAS  Google Scholar 

  91. Vanilla is anything but plain. Givaudan https://www.givaudan.com/taste-wellbeing/market-drivers/naturals/vanilla (2016).

  92. Derval, D. The Right Sensory Mix: Targeting Consumer Product Development Scientifically (Springer, 2010).

  93. Kuo, Y.-L., Pangborn, R. M. & Noble, A. C. Temporal patterns of nasal, oral, and retronasal perception of citral and vanillin and interaction of these odourants with selected tastants. Int. J. Food Sci. Technol. 28, 127–137 (1993).

    CAS  Google Scholar 

  94. Sakai, N., Kobayakawa, T., Gotow, N., Saito, S. & Imada, S. Enhancement of sweetness ratings of aspartame by a vanilla odor presented either by orthonasal or retronasal routes. Percept. Motor Skills 92, 1002–1008 (2001).

    CAS  PubMed  Google Scholar 

  95. Oliveira, A. A. A. et al. Use of strawberry and vanilla natural flavors for sugar reduction: a dynamic sensory study with yogurt. Food Res. Int. 139, 109972 (2021).

    CAS  PubMed  Google Scholar 

  96. Alcaire, F., Antúnez, L., Vidal, L., Giménez, A. & Ares, G. Aroma-related cross-modal interactions for sugar reduction in milk desserts: influence on consumer perception. Food Res. Int. 97, 45–50 (2017).

    CAS  PubMed  Google Scholar 

  97. Hoppert, K. et al. Consumer acceptance of regular and reduced-sugar yogurt enriched with different types of dietary fiber. Int. Dairy J. 28, 1–7 (2013).

    CAS  Google Scholar 

  98. Velázquez, A. L., Vidal, L., Varela, P. & Ares, G. Cross-modal interactions as a strategy for sugar reduction in products targeted at children: case study with vanilla milk desserts. Food Res. Int. 130, 108920 (2020).

    PubMed  Google Scholar 

  99. Wang, G., Hayes, J. E., Ziegler, G. R., Roberts, R. F. & Hopfer, H. Dose-response relationships for vanilla flavor and sucrose in skim milk: evidence of synergy. Beverages 4, 73 (2018).

    CAS  Google Scholar 

  100. Guo, J., Han, X., Zhan, J., You, Y. & Huang, W. Vanillin alleviates high fat diet-induced obesity and improves the gut microbiota composition. Front. Microbiol. 9, 2733 (2018).

    PubMed  PubMed Central  Google Scholar 

  101. Takai, E. et al. Effect of olfactory stimulation with vanilla odor on degree of electrical activity to control gastrointestinal motility. In Universal Access in Human-Computer Interaction. Access to Media, Learning and Assistive Environments HCII 2021 (eds Antona, A. & Stephanidis, C.) 519–530 (Springer, 2021); https://doi.org/10.1007/978-3-030-78095-1_38

  102. Kermen, F. et al. Molecular complexity determines the number odour notes and the pleasantness of smells. Sci. Rep. 1, 206 (2011).

    CAS  PubMed  PubMed Central  Google Scholar 

  103. Sezille, C., Fournel, A., Rouby, C., Rinck, F. & Bensafi, M. Hedonic appreciation and verbal description of pleasant and unpleasant odors in untrained, trainee cooks, flavorists, and perfumers. Front. Psychol. 5, 12 (2014).

    PubMed  PubMed Central  Google Scholar 

  104. Zarzo, M. Hedonic judgments of chemical compounds are correlated with molecular size. Sensors 11, 3667–3686 (2011).

    ADS  CAS  PubMed  PubMed Central  Google Scholar 

  105. Schiffman, S. S. Physiochemical correlates of olfactory quality. Science 185, 112–117 (1974).

    ADS  CAS  PubMed  Google Scholar 

  106. Engen, T. in Perfumery: The Psychology and Biology of Fragrance (eds Van Toller, S. & Dodd, G. H.) 79–90 (Chapman & Hall, 1988).

  107. Hermans, D. & Baeyens, F. in Olfaction, Taste, and Cognition (eds Rouby, C. et al.) 119–139 (Cambridge Univ. Press, 2002).

  108. Sell, C. Structure-odor relationships: on the unpredictability of odor. Angew. Chem. Int. Ed. 45, 6254–6261 (2006).

    CAS  Google Scholar 

  109. Keller, A. et al. Predicting human olfactory perception from chemical features of odor molecules. Science 355, 820–826 (2017).

    ADS  CAS  PubMed  PubMed Central  Google Scholar 

  110. Clarke, R. J. Coffee Vol. 1 (Springer, 2013).

  111. Rapp, A. Natural flavours of wine: correlation between instrumental analysis and sensory perception. Fresen. J. Anal. Chem. 337, 777–785 (1990).

    CAS  Google Scholar 

  112. Spence, C. & Wang, Q. J. On the meaning(s) of complexity in the chemical senses. Chem. Senses 43, 451–461 (2018).

    CAS  PubMed  Google Scholar 

  113. Tao, Y. S. & Li, H. Active volatiles of cabernet sauvignon wine from Changli county. Nat. Sci. 1, 176–182 (2009).

    Google Scholar 

  114. Dunkel, A. et al. Nature’s chemical signatures in human olfaction: a foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. 53, 7124–7143 (2014).

    CAS  Google Scholar 

  115. Gu, F., Chen, Y., Fang, Y., Wu, G. & Tan, L. Contribution of Bacillus isolates to the flavor profiles of vanilla beans assessed through aroma analysis and chemometrics. Molecules 20, 18422–18436 (2015).

    CAS  PubMed  PubMed Central  Google Scholar 

  116. Toth, S., Lee, K. J., Havkin-Frenkel, D., Belanger, F. C. & Hartman, T. G. in Handbook of Vanilla Science and Technology (eds Havkin-Frenkel, D. & Belanger, F. C.) 183–218 (Wiley-Blackwell, 2011).

  117. Zhang, S. & Mueller, C. Comparative analysis of volatiles in traditionally cured bourbon and Ugandan vanilla bean (Vanilla planifolia) extracts. J. Agric. Food Chem. 60, 10433–10444 (2012).

    CAS  PubMed  Google Scholar 

  118. Gleason-Allured, J. Vanilla: anything but plain. Perfumer and Flavorist http://www.perfumerflavorist.com/flavor/application/vanilla/132347233.html (2011).

  119. Lapid, H., Harel, D. & Sobel, N. Prediction models for the pleasantness of binary mixtures in olfaction. Chem. Senses 33, 599–609 (2008).

    PubMed  PubMed Central  Google Scholar 

  120. Balogh, R. D. & Porter, R. H. Olfactory preferences resulting from mere exposure in human neonates. Infant Behav. Dev. 9, 395–401 (1986).

    Google Scholar 

  121. Ishii, K. Does mere exposure enhance positive evaluation, independent of stimulus recognition? A replication study in Japan and the USA. Jpn Psychol. Res. 47, 280–285 (2005).

    Google Scholar 

  122. Monahan, J. L., Murphy, S. T. & Zajonc, R. B. Subliminal mere exposure: specific, general and affective effects. Psychol. Sci. 11, 462–466 (2000).

    CAS  PubMed  Google Scholar 

  123. Pliner, P. The effects of mere exposure on liking for edible substances. Appetite 3, 283–290 (1982).

    CAS  PubMed  Google Scholar 

  124. Varendi, H., Porter, R. H. & Winberg, J. Attractiveness for amniotic fluid odor: evidence for prenatal learning? Acta Paediatr. 85, 1223–1227 (1996).

    CAS  PubMed  Google Scholar 

  125. DeSnoo, K. Das trinkende kind im uterus [The drinking child in the uterus]. Monat. Geburtshilfe Gynäkol. 105, 88 (1937).

    Google Scholar 

  126. Marlier, L., Schaal, B. & Soussignan, R. Neonatal responsiveness to the odor of amniotic and lacteal fluids: a test of perinatal chemosensory continuity. Child Dev. 69, 611–623 (1998).

    CAS  PubMed  Google Scholar 

  127. Schaal, B., Marlier, L. & Soussignan, R. Neonatal responsiveness to the odour of amniotic fluid. Biol. Neonate 67, 397–406 (1995).

    CAS  PubMed  Google Scholar 

  128. Parker, G. H. & Stabler, E. M. On certain distinctions between taste and smell. Am. J. Physiol. 32, 230–240 (1913).

    Google Scholar 

  129. Sullivan, R. M. et al. Olfactory classical conditioning in neonates. Pediatrics 87, 511–518 (1991).

    CAS  PubMed  Google Scholar 

  130. Doucet, S., Soussignan, R., Sagot, P. & Schaal, B. The secretion of areolar (Montgomery’s) glands from lactating women elicits selective, unconditional responses in neonates. PLoS ONE 4, e7579 (2009).

    ADS  PubMed  PubMed Central  Google Scholar 

  131. Allen, J. New Yorkers sample cheese made from human breast milk. Reuters http://www.reuters.com/article/us-cheese-breastmilk-idUSTRE7413X020110502 (2011).

  132. Chappell, B. Breast milk ice cream a hit at London store. NPR https://www.npr.org/sections/thetwo-way/2011/02/25/134056923/breast-milk-ice-cream-a-hit-at-london-store (2011).

  133. Shah, K. Oh great, breast milk ice cream is back. Eater https://www.eater.com/2015/4/24/8491303/breast-milk-ice-cream-london-the-lickators-royal-baby (2015).

  134. Haller, R., Rummel, C., Henneberg, S., Pollmer, U. & Köster, E. The influence of early experience with vanillin in food preference later in life. Chem. Senses 24, 465–467 (1999).

    CAS  PubMed  Google Scholar 

  135. Mennella, J. A. & Beauchamp, G. The infant’s responses to flavored milk. Infant Behav. Dev. 17, 819 (1994).

    Google Scholar 

  136. Mennella, J. A. & Beauchamp, G. K. Early flavor experiences: when do they start? Nutr. Today 29, 25–31 (1994).

    Google Scholar 

  137. Mennella, J. A. & Beauchamp, G. K. The human infants’ response to vanilla flavors in mother’s milk and formula. Infant Behav. Dev. 19, 13–19 (1996).

    Google Scholar 

  138. Mennella, J. A. & Beauchamp, G. K. in Obesity Prevention: The Role of Brain and Society on Individual Behavior (eds Dubé, L. et al.) 203–217 (Elsevier, 2010).

  139. Newman, J. How breast milk protects newborns. Scientific American 76–79 (December 1995).

  140. Hepper, P. G. Adaptive fetal learning—prenatal exposure to garlic affects postnatal preferences. Anim. Behav. 36, 935–936 (1988).

    Google Scholar 

  141. Mennella, J. A. & Beauchamp, G. K. Maternal diet alters the sensory qualities of human milk and the nursling’s behavior. Pediatrics 88, 737–744 (1991).

    CAS  PubMed  Google Scholar 

  142. Mennella, J. A. & Beauchamp, G. K. The transfer of alcohol to human milk: effects on flavor and the infant’s behavior. New Engl. J. Med. 325, 981–985 (1991).

    CAS  PubMed  Google Scholar 

  143. Pollmer, U. Novel foods: flavour design and malnutrition. Agrofoodindustry Hi-Tech 2, 43–45 (1991).

    Google Scholar 

  144. Capretta, P. J., Petersik, J. T. & Steward, D. J. Acceptance of novel flavours is increased after early experience of diverse taste. Nature 254, 689–691 (1975).

    ADS  CAS  PubMed  Google Scholar 

  145. Forestell, C. A. Flavor perception and preference development in human infants. Ann. Nutr. Metab. 70, 17–25 (2017).

    PubMed  Google Scholar 

  146. Galef, B. G. & Sherry, D. F. Mother’s milk: a medium for transmission of cues reflecting the flavour of mother’s diet. J. Comp. Physiol. Psychol. 83, 374–378 (1973).

    PubMed  Google Scholar 

  147. Jerome, N. W. in Taste and Development: The Genesis of Sweet Preference (ed. Weiffenbach, J. M.) 235–248 (US Department of Health, Education, and Welfare, 1977).

  148. Steiner, J. E. in Advances in Child Development and Behaviour Vol. 13 (ed. Reese, H. W.) 257–295 (Academic, 1979).

  149. Soussignan, R., Schaal, B., Marlier, L. & Jiang, T. Facial and autonomic responses to biological and artificial olfactory stimuli in human neonates: re-examining early hedonic discrimination of odors. Physiol. Behav. 62, 745–758 (1997).

    CAS  PubMed  Google Scholar 

  150. Mennella, J. A. & Beauchamp, G. K. Infants’ exploration of scented toys: effects of prior experience. Chem. Senses 23, 11–17 (1998).

    CAS  PubMed  Google Scholar 

  151. Schaal, B., Marlier, L. & Soussignan, R. Human foetuses learn odours from their pregnant mother’s diet. Chem. Senses 25, 729–737 (2000).

    CAS  PubMed  Google Scholar 

  152. Mennella, J. A., Jagnow, C. P. & Beauchamp, G. K. Prenatal and postnatal flavor learning by human infants. Pediatrics 107, e88 (2001).

    CAS  PubMed  Google Scholar 

  153. Hausner, H., Bredie, W. L. P., Mølgaard, C., Petersen, M. A. & Møller, P. Differential transfer of dietary flavour compounds into human breast milk. Physiol. Behav. 95, 118–124 (2008).

    CAS  PubMed  Google Scholar 

  154. Loos, H. M., Reger, D. & Schaal, B. The odour of human milk: its chemical variability and detection by newborns. Physiol. Behav. 199, 88–99 (2019).

    CAS  PubMed  Google Scholar 

  155. Ventura, A. K. & Mennella, J. A. Innate and learned preferences for sweet taste during childhood. Curr. Opin. Clin. Nutr. Metab. Care 14, 379–384 (2011).

    PubMed  Google Scholar 

  156. Holy, T. E. Scenting Waldo: analyzing olfactory scenes. Nat. Neurosci. 17, 1144–1145 (2014).

    CAS  PubMed  Google Scholar 

  157. Rokni, D., Hemmelder, V., Kapoor, V. & Murthy, V. N. An olfactory cocktail party: figure-ground segregation of odorants in rodents. Nat. Neurosci. 17, 1225–1232 (2014).

    CAS  PubMed  PubMed Central  Google Scholar 

  158. Rokni, D. & Murthy, V. N. Analysis and synthesis in olfaction. ACS Chem. Neurosci. 5, 870–872 (2014).

    CAS  PubMed  Google Scholar 

  159. Spence, C. Flavour pairing: a critical review of the literature on food and beverage pairing. Food Res. Int. 133, 109124 (2020).

    CAS  PubMed  Google Scholar 

  160. Spence, C. Gastrophysics: getting creative with pairing flavours. Int. J. Gastron. Food Sci. 27, 100433 (2022).

    Google Scholar 

  161. Moskowitz, H. R., Dravnieks, A. & Klarman, L. A. Odor intensity and pleasantness for a diverse set of odorants. Percept. Psychophys. 19, 122–128 (1976).

    Google Scholar 

  162. Doty, R. et al. Intranasal trigeminal stimulation from odorous volatiles: psychometric responses from anosmic and normal humans. Physiol. Behav. 20, 175–185 (1978).

    CAS  PubMed  Google Scholar 

  163. Frasnelli, J., Hummel, T., Berg, J., Huang, G. & Doty, R. L. Intranasal localizability of odorants: influence of stimulus volume. Chem. Senses 36, 405–410 (2011).

    CAS  PubMed  PubMed Central  Google Scholar 

  164. Kobal, G. & Hummel, T. Olfactory and intranasal trigeminal event-related potentials in anosmic patients. Laryngoscope 108, 1033–1035 (1998).

    CAS  PubMed  Google Scholar 

  165. Savic, I., Gulyás, B. & Berglund, H. Odorant differentiated pattern of cerebral activation: comparison of acetone and vanillin. Human Brain Mapp. 17, 17–27 (2002).

    Google Scholar 

  166. Wu, S. W., Fowler, D. K., Shaffer, F. J., Lindberg, J. E. M. & Peters, J. H. Ethyl vanillin activates TRPA1. J. Pharmacol. Exp. Ther. 362, 368–377 (2017).

    CAS  PubMed  PubMed Central  Google Scholar 

  167. Midroit, M. et al. Neural processing of the reward value of pleasant odorants. Curr. Biol. 31, 1592–1605.e9 (2021).

    CAS  PubMed  PubMed Central  Google Scholar 

  168. Wilson, D. A. & East, B. S. Good scents: a short road from olfaction to satisfaction. Curr. Biol. 31, R374–R376 (2021).

    CAS  PubMed  Google Scholar 

  169. Mennella, J. A., Pepino, M. Y. & Reed, D. R. Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics 115, e216–e222 (2005).

    PubMed  Google Scholar 

  170. Eriksson, N. et al. A genetic variant near olfactory receptor genes influences cilantro preference. Flavour 1, 22 (2012).

    Google Scholar 

  171. Mauer, L. & El-Sohemy, A. Prevalence of cilantro (Coriandrum sativum) disliking among different ethnocultural groups. Flavour 1, 8 (2012).

    Google Scholar 

  172. McGee, H. Cilantro haters, it’s not your fault. The New York Times http://www.nytimes.com/2010/04/14/dining/14curious.html?_r=0 (2010).

  173. Wysocki, C. J. & Beauchamp, G. K. Ability to smell androstenone is genetically determined. Proc. Natl Acad. Sci. USA 81, 4899–4902 (1984).

    ADS  CAS  PubMed  PubMed Central  Google Scholar 

  174. Howgego, J. Sense for scents traced down to genes. Nat. Neurosci. https://doi.org/10.1038/nature.2013.13493 (2013).

  175. Reed, D. R. & Knaapila, A. Genetics of taste and smell: poisons and pleasures. Progr. Mol. Biol. Transl. Sci. 94, 213–240 (2010).

    CAS  Google Scholar 

  176. Jaeger, S. R. et al. A Mendelian trait for olfactory sensitivity affects odor experience and food selection. Curr. Biol. 23, 1601–1605 (2013).

    CAS  PubMed  Google Scholar 

  177. McRae, J. F. et al. Identification of regions associated with variation in sensitivity to food-related odors in the human genome. Curr. Biol. 23, 1596–1600 (2013).

    CAS  PubMed  Google Scholar 

  178. Pelchat, M. L., Bykowski, C., Dule, F. F. & Reed, D. R. Excretion and perception of a characteristic odor in urine after asparagus ingestion: a psychophysical and genetic study. Chem. Senses 36, 9–17 (2011).

    CAS  PubMed  Google Scholar 

  179. Plotto, A., Barnes, K. W. & Goodner, K. L. Specific anosmia observed for β-ionone, but not for α-ionone: significance for flavour research. J. Food Sci. 71, 401–406 (2006).

    Google Scholar 

  180. Simmen, D. & Briner, H. R. Olfaction in rhinology—methods of assessing the sense of smell. Rhinology 44, 98–101 (2006).

    PubMed  Google Scholar 

  181. Axel, R. The molecular logic of smell. Sci. Am. 273, 154–159 (1995).

    CAS  PubMed  Google Scholar 

  182. Ravia, A. et al. A measure of smell enables the creation of olfactory metamers. Nature 588, 118–123 (2020).

    ADS  CAS  PubMed  Google Scholar 

  183. Schaal, B., Saxton, T. K., Loos, H., Soussignan, R. & Durand, K. Olfaction scaffolds the developing human from neonate to adolescent and beyond. Phil. Trans. R. Soc. B 375, 20190261 (2020).

    PubMed  PubMed Central  Google Scholar 

  184. Wilson, D. A. & Stevenson, R. J. Learning to Smell (Johns Hopkins Univ. Press, 2006).

  185. Blank, D. M. & Mattes, R. D. Sugar and spice: similarities and sensory attributes. Nurs. Res. 39, 290–293 (1990).

    CAS  PubMed  Google Scholar 

  186. Hsiao, Y.-Y. et al. Research on orchid biology and biotechnology. Plant Cell Physiol. 52, 1467–1486 (2011).

    CAS  PubMed  Google Scholar 

  187. Herz, R. S. et al. A three-factor benefits framework for understanding consumer preference for scented household products: psychological interactions and implications for future development. Cogn. Res. 7, 28 (2022).

    Google Scholar 

  188. Wang, X. et al. Support for natural small-molecule phenols as anxiolytics. Molecules 22, 2138 (2017).

    PubMed Central  Google Scholar 

  189. Hunt, S. R. Sugar and spice. Pharmaceut. J. 191, 632–635 (1963).

    CAS  Google Scholar 

  190. Beauchamp, G. K. Why do we like sweet taste: a bitter tale? Physiol. Behav. 164, 432–437 (2016).

    CAS  PubMed  PubMed Central  Google Scholar 

  191. Beidler, L. M. in Sweeteners: Issues and Uncertainties Vol. 4, 11–18 (National Academy of Sciences, 2016).

  192. Moskowitz, H. in Sugars in Nutrition (eds Sipple, H. L. & McNutt, K. W.) 37–64 (Academic, 1974).

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Charles Spence.

Ethics declarations

Competing interests

The author declares no competing interests.

Peer review

Peer review information

Nature Food thanks Moustafa Bensafi and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Spence, C. Odour hedonics and the ubiquitous appeal of vanilla. Nat Food 3, 837–846 (2022). https://doi.org/10.1038/s43016-022-00611-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43016-022-00611-x

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing