Acute and chronic maternal exposure to fine particulate matter and prelabor rupture of the fetal membranes: A nation-wide survey in China

Highlights

• This is the largest nationwide study to examine the associations of maternal PM_2.5 exposure with PROM in China.

• Both acute and chronic maternal ambient PM_2.5 exposure increased the risk of PROM.

• Women who were less educated, obese, or delivered in a cold season were more sensitive to PM_2.5 exposure.

Abstract

Background

Prelabor rupture of the fetal membranes (PROM) is a major contributor to adverse perinatal outcomes. Some epidemiologic studies explored the association between maternal PM_2.5 exposure and PROM but failed to treat the labor induction and prelabor cesarean section as censored observations.

Objective

We aimed to evaluated whether acute and chronic maternal ambient PM_2.5 exposure may increase the risk of PROM in China.

Methods

This study was based on the China Labor and Delivery Survey, a nationwide multicenter investigation. Included in the current analysis were 45,879 singleton spontaneous births in 96 hospitals in mainland China from 2015 to 2017. Outcomes were PROM, preterm PROM (<37 weeks’ gestation) and term PROM (≥37 weeks’ gestation). Daily concentration of PM_2.5 at 1 km spatial resolution was estimated by gap-filling model. Generalized linear mixed model and mixed effects Cox model were applied to assess the associations of acute (from 0 to 4 days before delivery) and chronic (average gestational and trimester-specific) ambient PM_2.5 exposure with outcomes, respectively.

Results

Significant associations were found between acute PM_2.5 exposures (per interquartile range increase) and the risk of preterm PROM (OR = 1.11; 95 % CI: 1.03, 1.19 for PM_2.5 on delivery day; OR = 1.10; 95 % CI: 1.02, 1.18 for PM_2.5 1 day before delivery) but not for term PROM. An interquartile range increase in PM_2.5 during the second trimester was associated with elevated risks of PROM (HR = 1.14; 95 % CI: 1.07, 1.22), preterm PROM (HR = 1.22; 95 % CI: 1.02, 1.45) and term PROM (HR = 1.13; 95 % CI: 1.06, 1.22), respectively. Women who were less educated, obese, or gave birth in a cold season appeared to be more sensitive to ambient PM_2.5 exposure.

Conclusion

Our findings suggest that both acute and chronic maternal exposures to ambient PM_2.5 during pregnancy are risk factors for PROM.