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Gut microbiota

Disarming the pathogen

Nature Chemical Biology volume 19, pages 5–6 (2023)Cite this article

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The gut microbiota has a key role in protecting hosts from pathogens. A new study identified a gut microbiota-derived bile acid (chenodeoxycholic acid) that inhibits bacterial infection by interacting with a regulatory protein necessary for the expression of virulence factors.

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Fig. 1: Gut microbiota-derived CDCA deactivates Salmonella virulence.

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Authors and Affiliations

  1. Natural Sciences Department, Metropolitan Autonomous University-Cuajimalpa, Mexico City, Mexico

    Deyanira Pérez-Morales

  2. Department of Molecular Microbiology, Biotechnology Institute, National Autonomous University of Mexico, Cuernavaca, Morelos, Mexico

    Víctor H. Bustamante

Authors
  1. Deyanira Pérez-Morales
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  2. Víctor H. Bustamante
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Correspondence to Víctor H. Bustamante.

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The authors declare no competing interests.

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Pérez-Morales, D., Bustamante, V.H. Disarming the pathogen. Nat Chem Biol 19, 5–6 (2023). https://doi.org/10.1038/s41589-022-01133-0

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