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Effects of dexmedetomidine on oxygenation and inflammatory factors in patients undergoing uvulopalatopharyngoplasty: a prospective, randomized, placebo-controlled trial

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Purpose

Uvulopalatopharyngoplasty (UPPP) can aggravate lung inflammatory reactions in patients with obstructive sleep apnoea syndrome (OSAS). Dexmedetomidine (Dex) is a selective α-2 adrenoreceptor agonist that can alleviate lung injury. This study was designed to investigate the effects of Dex on oxygenation and inflammatory factors in patients undergoing UPPP in the early perioperative period.

Methods

Patients with OSAS undergoing UPPP were randomly allocated to the Dex Group or Control Group. Arterial blood gas analyses were performed, and the respiratory index (RI) and oxygenation index (OI) were calculated upon entering the operating room (T0) and immediately after surgery (T3). The inflammatory factors tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) were measured at T0 and T3.

Results

A total of 44 patients with OSAS were randomized. There was no significant difference in basic patient characteristics between the two groups. The preoperative RI and OI were not significantly different between the two groups, but they were altered immediately after surgery relative to the corresponding preoperative value (p < 0.05). Compared with the Control Group, the RI was significantly lower at T3 in the Dex Group (p < 0.001). However, there was no significant difference in the OI between the two groups (p = 0.128). The inflammatory factors TNF-α (p < 0.001) and IL-6 (p = 0.018) were lower, while IL-10 was higher in the Dex Group than in the Control Group (p < 0.001).

Conclusion

Dexmedetomidine can improve the oxygenation and inhibit the inflammatory response in patients undergoing UPPP in the early perioperative period.

Trial registration

The present clinical study has been registered at Clinical Trials under number NCT03612440.

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Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

We gratefully acknowledge the participants and staff members at the General Hospital of Ningxia Medical University.

Funding

This work was supported by the National Natural Science Foundation of China (grant number: 81660198) and the Key Research and Development Program of Ningxia (grant number: 2021BEG03048).

Author information

Author notes

  1. Na Li and Yonghai Zhang contributed equally to this work.

Authors and Affiliations

  1. Department of Anaesthesiology, Ningxia Medical University, Yinchuan, 750004, China

    Na Li, Xiaoyang Yu, Kaimei Lu & Jie Wang

  2. Department of Anaesthesiology, General Hospital of Ningxia Medical University, Yinchuan, 750004, China

    Yonghai Zhang, Fan Yang, Huiwen Zhang, Hanxiang Ma & Xinli Ni

Authors
  1. Na Li
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Contributions

Na Li and Yonghai Zhang contributed to the design of the work, analysis of the data, and drafting of the manuscript. Fan Yang, Huiwen Zhang, Xiaoyang Yu, Xiaoyang Yu, Kaimei Lu and Jie Wang contributed to the acquisition, analysis, and interpretation of the data. Hanxiang Ma and Xinli Ni contributed to the project administration support and design of the work and wrote the original draft. All authors read and revised the manuscript and approved the final version.

Corresponding authors

Correspondence to Hanxiang Ma or Xinli Ni.

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Ethics approval

This study was approved by the Ethics Committee of the General Hospital of Ningxia Medical University (No. 2018–243) and conducted in accordance with the World Medical Association Declaration of Helsinki. All participants signed written informed consent forms.

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Informed consent was obtained from all individual participants included in the study or their guardians.

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The authors declare no competing interests.

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Li, N., Zhang, Y., Yang, F. et al. Effects of dexmedetomidine on oxygenation and inflammatory factors in patients undergoing uvulopalatopharyngoplasty: a prospective, randomized, placebo-controlled trial. Sleep Breath 27, 1099–1106 (2023). https://doi.org/10.1007/s11325-022-02711-1

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  • DOI: https://doi.org/10.1007/s11325-022-02711-1

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