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Imaging probes

Non-invasive monitoring of autophagy

Nature Biomedical Engineering volume 6, pages 1015–1016 (2022)Cite this article

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The flux of autophagosomes in heart tissue can be detected in live mice via the fluorescence and magnetic resonance properties of intravenously injected iron oxide nanoparticles decorated with fluorescent peptides cleavable by lysosomal cathepsins.

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Fig. 1: In vivo monitoring of autophagy via an enzyme-activatable nanoparticle probe with fluorescence and magnetic-resonance readouts.

References

  1. Feng, Y., He, D., Yao, Z. & Klionsky, D. J. Cell Res. 24, 24–41 (2014).

    Article  CAS  Google Scholar 

  2. Jiang, P. & Mizushima, N. Cell Res. 24, 69–79 (2014).

    Article  CAS  Google Scholar 

  3. Klionsky, D. J. et al. Autophagy 17, 1–382 (2021).

    Article  Google Scholar 

  4. Tanida, I., Minematsu-Ikeguchi, N., Ueno, T. & Kominami, E. Autophagy 1, 84–91 (2005).

    Article  CAS  Google Scholar 

  5. Loos, B., Toit, A. D. & Hofmeyr, J. H. S. Autophagy 10, 2087–2096 (2014).

    Article  Google Scholar 

  6. Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T. & Ohsumi, Y. J. Mol. Cell Biol. 15, 1101–1111 (2004).

    Article  CAS  Google Scholar 

  7. Iwai-Kanai, E. et al. Autophagy 4, 322–329 (2008).

    Article  CAS  Google Scholar 

  8. Haspel, J. et al. Autophagy 7, 629–642 (2011).

    Article  CAS  Google Scholar 

  9. Hariharan, N., Zhai, P. & Sadoshima, J. Antioxid. Redox Signal. 14, 2179–2190 (2011).

    Article  CAS  Google Scholar 

  10. Kaizuka, T. et al. Mol. Cell 64, 835–849 (2016).

    Article  CAS  Google Scholar 

  11. Chen, H. H. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-022-00904-3 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Cataldo, A. M., Barnett, J. L., Pieroni, C. & Nixon, R. A. J. Neurosci. 17, 6142–6151 (1997).

    Article  CAS  Google Scholar 

  13. du Toit, A., Hofmeyr, J. H. S., Gniadek, T. J. & Loos, B. Autophagy 14, 1060–1071 (2018).

    PubMed  PubMed Central  Google Scholar 

  14. Hyun, H. et al. Nat. Med. 21, 192–197 (2015).

    Article  CAS  Google Scholar 

  15. Loos, B., Klionsky, D. J., Du Toit, A. & Hofmeyr, J. H. S. Autophagy 16, 750–762 (2020).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa

    Ben Loos & Andre du Toit

  2. Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa

    Jan-Hendrik S. Hofmeyr

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  1. Ben Loos
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  2. Andre du Toit
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  3. Jan-Hendrik S. Hofmeyr
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Correspondence to Ben Loos.

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Loos, B., du Toit, A. & Hofmeyr, JH.S. Non-invasive monitoring of autophagy. Nat. Biomed. Eng 6, 1015–1016 (2022). https://doi.org/10.1038/s41551-022-00943-w

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