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Expanding the spectrum of amyloid-β plaque pathology: the Down syndrome associated ‘bird-nest plaque’

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References

  1. Boon BDC, Bulk M, Jonker AJ et al (2020) The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer’s disease. Acta Neuropathol 140:811–830. https://doi.org/10.1007/s00401-020-02198-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Boon BDC, Hoozemans JJM, Lopuhaa B et al (2018) Neuroinflammation is increased in the parietal cortex of atypical Alzheimer’s disease. J Neuroinflammation 15:170. https://doi.org/10.1186/s12974-018-1180-y

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Drummond E, Kavanagh T, Pires G et al (2022) The amyloid plaque proteome in early onset Alzheimer’s disease and Down syndrome. Acta Neuropathol Commun 10:53. https://doi.org/10.1186/s40478-022-01356-1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Ichimata S, Yoshida K, Visanji NP, Lang AE, Nishida N, Kovacs GG (2022) Patterns of mixed pathologies in Down syndrome. J Alzheimers Dis 87:595–607. https://doi.org/10.3233/JAD-215675

    Article  CAS  PubMed  Google Scholar 

  5. Schmidt ML, Robinson KA, Lee VM, Trojanowski JQ (1995) Chemical and immunological heterogeneity of fibrillar amyloid in plaques of Alzheimer’s disease and Down’s syndrome brains revealed by confocal microscopy. Am J Pathol 147:503–515

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Wilcock DM, Griffin WS (2013) Down’s syndrome, neuroinflammation, and Alzheimer neuropathogenesis. J Neuroinflammation 10:84. https://doi.org/10.1186/1742-2094-10-84

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Willumsen N, Poole T, Nicholas JM, Fox NC, Ryan NS, Lashley T (2022) Variability in the type and layer distribution of cortical Aβ pathology in familial Alzheimer’s disease. Brain Pathol 32(3):e13009. https://doi.org/10.1111/bpa.13009

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

Brain samples were obtained through appropriate consenting procedures with Local Ethic Committee approval and approved by the University Health Network Research Ethics Board (Nr. 20–5258). This study was supported by the Edmond J Safra Philanthropic Foundation and the Rossy Family Foundation and Canadian Foundation for Innovation (40480) and the Ontario Research Fund.

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Authors and Affiliations

  1. Tanz Centre for Research in Neurodegenerative Disease, Krembil Discovery Tower, University of Toronto, 60 Leonard Ave Toronto On, Toronto, ON, M5T 0S8, Canada

    Shojiro Ichimata, Ivan Martinez-Valbuena, Shelley L. Forrest & Gabor G. Kovacs

  2. Department of Laboratory Medicine and Pathobiology and Department of Medicine, University of Toronto, Toronto, ON, Canada

    Shojiro Ichimata & Gabor G. Kovacs

  3. Department of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan

    Shojiro Ichimata

  4. Dementia Research Centre, Macquarie Medical School, Faculty of Health and Human Sciences, Macquarie University, Sydney, Australia

    Shelley L. Forrest

  5. Laboratory Medicine Program & Krembil Brain Institute, University Health Network, Toronto, ON, Canada

    Shelley L. Forrest & Gabor G. Kovacs

Authors
  1. Shojiro Ichimata
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  2. Ivan Martinez-Valbuena
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  3. Shelley L. Forrest
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  4. Gabor G. Kovacs
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Corresponding author

Correspondence to Gabor G. Kovacs.

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GGK is member of the Acta Neuropathologica Editorial Board, but was not involved in the editorial handling of this article. SI, IMV, and SF declare no competing interest.

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Ichimata, S., Martinez-Valbuena, I., Forrest, S.L. et al. Expanding the spectrum of amyloid-β plaque pathology: the Down syndrome associated ‘bird-nest plaque’. Acta Neuropathol 144, 1171–1174 (2022). https://doi.org/10.1007/s00401-022-02500-w

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  • DOI: https://doi.org/10.1007/s00401-022-02500-w

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