Artificial intelligence in microbial natural product drug discovery: current and emerging role

Vinodh J. Sahayasheela; Manendra B. Lankadasari; Vipin Mohan Dan; Syed G. Dastager; Ganesh N. Pandian; Hiroshi Sugiyama

doi:10.1039/D2NP00035K

Artificial intelligence in microbial natural product drug discovery: current and emerging role

Vinodh J. Sahayasheela,

^a Manendra B. Lankadasari,^b Vipin Mohan Dan,^c Syed G. Dastager,

*^d Ganesh N. Pandian

*^e and Hiroshi Sugiyama

*^ae

Author affiliations

* Corresponding authors

^a Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto 606-8502, Japan
E-mail: sugiyama.hiroshi.3s@kyoto-u.ac.jp

^b Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA

^c Microbiology Division, Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Thiruvananthapuram, Kerala, India

^d NCIM Resource Centre, Division of Biochemical Sciences, CSIR - National Chemical Laboratory, Pune, Maharashtra, India

^e Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida-Ushinomaecho, Sakyo-Ku, Kyoto 606-8501, Japan

Abstract

Covering: up to the end of 2022

Microorganisms are exceptional sources of a wide array of unique natural products and play a significant role in drug discovery. During the golden era, several life-saving antibiotics and anticancer agents were isolated from microbes; moreover, they are still widely used. However, difficulties in the isolation methods and repeated discoveries of the same molecules have caused a setback in the past. Artificial intelligence (AI) has had a profound impact on various research fields, and its application allows the effective performance of data analyses and predictions. With the advances in omics, it is possible to obtain a wealth of information for the identification, isolation, and target prediction of secondary metabolites. In this review, we discuss drug discovery based on natural products from microorganisms with the help of AI and machine learning.

Graphical abstract: Artificial intelligence in microbial natural product drug discovery: current and emerging role

Article information

https://doi.org/10.1039/D2NP00035K

Article type

Review Article

Submitted

10 May 2022

First published

26 Aug 2022

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Nat. Prod. Rep., 2022,39, 2215-2230

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Artificial intelligence in microbial natural product drug discovery: current and emerging role

V. J. Sahayasheela, M. B. Lankadasari, V. M. Dan, S. G. Dastager, G. N. Pandian and H. Sugiyama, Nat. Prod. Rep., 2022, 39, 2215 DOI: 10.1039/D2NP00035K

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Artificial intelligence in microbial natural product drug discovery: current and emerging role

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