Data from the EULAR COVAX physician-reported registry indicate that disease flares and serious adverse events rarely occur after SARS-CoV-2 vaccination in adolescents with inflammatory rheumatic and musculoskeletal diseases (RMD) and adults with juvenile idiopathic arthritis (JIA). RMD flare occurred in 1 of the 36 adolescents and 2 of the 74 adults in the dataset; only one serious adverse event was reported, in the adolescent group. Mild to moderate adverse events were common, but their frequency and profile was similar to that seen in the general population.