Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

FUNGAL GENETICS

Telomere transposon takeover in Cryptococcus

Identification and analysis of mutator strains in the human fungal pathogen Cryptococcus neoformans show that natural loss of RNA interference triggers massive accumulation of Cnl1 retroelements at subtelomeric regions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Flow diagram of screening approach and key findings.

References

  1. Lynch, M. et al. Nat. Rev. Genet. 17, 704–714 (2016).

    Article  CAS  Google Scholar 

  2. Matic, I. Mol. Cell. 75, 421–425 (2019).

    Article  CAS  Google Scholar 

  3. Bui, D. T. et al. Genetics 205, 1459–1471 (2017).

    Article  CAS  Google Scholar 

  4. Bourque, G. et al. Genome Biol. 19, 199 (2018).

    Article  CAS  Google Scholar 

  5. Cosby, R. L., Chang, N. C. & Feschotte, C. Genes Dev. 33, 1098–1116 (2019).

    Article  CAS  Google Scholar 

  6. Kibbler, C. C. et al. Oxford Textbook of Medical Mycology (Oxford Univ. Press, 2017).

  7. Priest, S. J. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-022-01183-z (2022).

    Article  PubMed  Google Scholar 

  8. Feretzaki, M. & Heitman, J. PLoS Genet. 9, e1003688 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hiten D. Madhani.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Huang, M.Y., Madhani, H.D. Telomere transposon takeover in Cryptococcus. Nat Microbiol 7, 1108–1109 (2022). https://doi.org/10.1038/s41564-022-01189-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41564-022-01189-7

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing