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Ultrasound-Assisted Anti-Solvent Crystallization of Ibuprofen: Effect of Ultrasonic Treatment and Additive

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Abstract

Purpose

This study aims to determine the effect of ultrasonic treatment and additive on the morphology, physicochemical properties, and dissolution of ibuprofen crystals.

Methods

Ultrasound-assisted anti-solvent crystallization was used to form ibuprofen crystals. The produced crystals were tested for various physicochemical properties.

Results

The morphology of the ibuprofen crystals was significantly altered in terms of size and shape after the anti-solvent crystallization process and ultrasonic treatment. The melting range of ibuprofen remained unaltered when measured via differential scanning calorimetry. The powder X-ray diffractometry analysis confirmed the presence of ibuprofen in a crystalline state. The anti-solvent addition at various times following ultrasonic treatment had no significant effect on drug dissolution. However, the polyethylene glycol (PEG) 400 and polysorbate 80 additives increased drug dissolution. The addition of 20% w/w PEG or polysorbate 80 resulted in higher drug dissolution than 10% w/w PEG or polysorbate 80.

Conclusion

The results demonstrate that the ultrasound-assisted crystallization of the anti-solvent with an appropriate duration affected the physical and chemical properties of treated ibuprofen crystals, making them more soluble, particularly when polysorbate 80 was used.

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Acknowledgements

We gratefully acknowledge financial support from the Royal Golden Jubilee Ph.D. Program, Thailand. Thanks to Waraporn Kuyukham, Karakadaporn Pimnoo, and Pannin Lapkern for performing preliminary experiments.

Funding

The study received financial support from the Royal Golden Jubilee PhD program, Thailand.

Author information

Authors and Affiliations

  1. School of Pharmacy, Eastern Asia University, Rangsit, Pathumthani, 12110, Thailand

    Kampanart Huanbutta

  2. Pharmaceutical Biopolymer Group (PBiG), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand

    Kampanart Huanbutta, Tanikan Sangnim, Rattanawich Minphimai, Suchada Piriyaprasarth, Sontaya Limmatvapirat & Pornsak Sriamornsak

  3. Faculty of Pharmaceutical Sciences, Burapha University, Saen Suk, Chonburi, 20131, Thailand

    Tanikan Sangnim

  4. Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand

    Rattanawich Minphimai, Suchada Piriyaprasarth, Sontaya Limmatvapirat & Pornsak Sriamornsak

  5. Academy of Science, The Royal Society of Thailand, Bangkok, 10300, Thailand

    Pornsak Sriamornsak

Authors
  1. Kampanart Huanbutta
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  2. Tanikan Sangnim
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  3. Rattanawich Minphimai
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  4. Suchada Piriyaprasarth
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  5. Sontaya Limmatvapirat
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  6. Pornsak Sriamornsak
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Contributions

The study conception and design were performed by Pornsak Sriamornsak and Rattanawich Minphimai. Material preparation, data collection, and analysis were performed by Kampanart Huanbutta, Rattanawich Minphimai, Suchada Piriyaprasarth, Sontaya Limmatvapirat, and Pornsak Sriamornsak. The first draft of the manuscript was written by Kampanart Huanbutta, Tanikan Sangnim, and Pornsak Sriamornsak, and all the authors commented on the previous versions of the manuscript. All the authors read and approved the final manuscript.

Corresponding author

Correspondence to Pornsak Sriamornsak.

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The authors declare no competing interests.

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Huanbutta, K., Sangnim, T., Minphimai, R. et al. Ultrasound-Assisted Anti-Solvent Crystallization of Ibuprofen: Effect of Ultrasonic Treatment and Additive. J Pharm Innov 18, 575–584 (2023). https://doi.org/10.1007/s12247-022-09674-6

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  • DOI: https://doi.org/10.1007/s12247-022-09674-6

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