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METABOLIC HOMEOSTASIS

Prolonged lactation benefits offspring metabolism

Nature Metabolism volume 4, pages 798–799 (2022)Cite this article

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Longer duration of breastfeeding is shown to have long-lasting effects in rodents, which lead to an adult phenotype that is resistant to diet-induced obesity and has increased brown adipose tissue activity through a process dependent on hypothalamic FGF21 signalling.

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Fig. 1: Effects of prolonged lactation.

References

  1. Kusuyama, J., Alves-Wagner, A. B., Makarewicz, N. S. & Goodyear, L. J. Nat. Metab. 2, 858–872 (2020).

    Article  Google Scholar 

  2. Kereliuk, S. M., Brawerman, G. M. & Dolinsky, V. W. Int. J. Mol. Sci. 18, 1451 (2017).

    Article  Google Scholar 

  3. Dearden, L. & Ozanne, S. E. Front. Neuroendocrinol. 39, 3–16 (2015).

    Article  Google Scholar 

  4. Pena-León, V. et al. Nat. Metab. https://doi.org/10.1038/s42255-022-00602-z (2022).

    Article  Google Scholar 

  5. Waddington, C. H. The Epigenotpye. Endeavour 1, 18–20 (1942).

    Google Scholar 

  6. Lin, X. H. et al. Sci. Rep. 11, 316 (2021).

    Article  CAS  Google Scholar 

  7. Kusuyama, J. et al. Cell Metab. 33, 939–956.e8 (2021).

    Article  CAS  Google Scholar 

  8. Han, L. et al. Nat. Genet. 50, 432–442 (2018).

    Article  CAS  Google Scholar 

  9. Gu, T. P. et al. Nature 477, 606–610 (2011).

    Article  CAS  Google Scholar 

  10. Hondares, E. et al. Cell Metab. 11, 206–212 (2010).

    Article  CAS  Google Scholar 

  11. Flippo, K. H. & Potthoff, M. J. Nat. Metab. 3, 309–317 (2021).

    Article  CAS  Google Scholar 

  12. Folgueira, C. et al. Nat. Metab. 1, 811–829 (2019).

    Article  CAS  Google Scholar 

  13. Cheshmeh, S., Nachvak, S. M., Rezvani, N. & Saber, A. Diabetes Metab. Syndr. Obes. 13, 2227–2237 (2020).

    Article  CAS  Google Scholar 

  14. Becher, T. et al. Nat. Med. 27, 58–65 (2021).

    Article  CAS  Google Scholar 

  15. Carpentier, A. C. et al. Front. Endocrinol. 9, 447 (2018).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA

    Elisa Félix-Soriano & Kristin I. Stanford

  2. Department of Physiology and Cell Biology, The Ohio State University College of Medicine, Columbus, OH, USA

    Elisa Félix-Soriano & Kristin I. Stanford

  3. Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, USA

    Kristin I. Stanford

Authors
  1. Elisa Félix-Soriano
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  2. Kristin I. Stanford
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Correspondence to Kristin I. Stanford.

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Félix-Soriano, E., Stanford, K.I. Prolonged lactation benefits offspring metabolism. Nat Metab 4, 798–799 (2022). https://doi.org/10.1038/s42255-022-00604-x

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