Issue 66, 2022
From the journal:

Chemical Communications

Nickel-catalyzed cross-coupling of epoxides with aryltriflates: rapid and regioselective construction of aryl ketones†

Jinglin Qu,‡a   Zijuan Yan,‡a   Xuchao Wang,a   Jun Deng,b   Feipeng Liu*a  and  Zi-Qiang Rong ORCID logo *a  

* Corresponding authors

a Frontiers Science Center for Flexible Electronics (FSCFE), Shaanxi Institute of Flexible Electronics (SIFE) & Shaanxi Institute of Biomedical Materials and Engineering (SIBME), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an, P. R. China
E-mail: iamfpliu@nwpu.edu.cn, iamzqrong@nwpu.edu.cn

b Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, P. R. China

Abstract

Aryl ketones are one of the most important classes of organic compounds, and widely present in various pharmacological compounds, biologically active molecules and functional materials. Presented herein is a facile synthetic method for the construction of ketones via Ni-catalyzed cross coupling of epoxides with aryltriflates. A range of easily accessible epoxides can be highly regioselectively converted to the corresponding aryl ketones with good yields in a redox neutral fashion.

Graphical abstract: Nickel-catalyzed cross-coupling of epoxides with aryltriflates: rapid and regioselective construction of aryl ketones

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Article information

DOI
https://doi.org/10.1039/D2CC02891C
Article type
Communication
Submitted
22 May 2022
Accepted
20 Jul 2022
First published
22 Jul 2022

Chem. Commun., 2022,58, 9214-9217

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Nickel-catalyzed cross-coupling of epoxides with aryltriflates: rapid and regioselective construction of aryl ketones

J. Qu, Z. Yan, X. Wang, J. Deng, F. Liu and Z. Rong, Chem. Commun., 2022, 58, 9214 DOI: 10.1039/D2CC02891C

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