Issue 15, 2022

Insight into ultrasensitive and high-stability flocculation-enhanced Raman spectroscopy for the in situ noninvasive probing of cupping effect substances

Abstract

The aggregation of nanoparticles is the key factor to form hot spots for the flocculation-enhanced Raman spectroscopy (FLERS) method. However, the structure of flocculation is still not clear. It is therefore necessary to explore and analyze the aggregation process of nanoparticles more carefully, so as to realize a better application of FLERS. Here, we report the application of in situ liquid cell transmission electron microscopy (TEM) combined with an in situ high-speed camera to analyze the particle behaviors. The results showed that flocculation can exist stably and the gap between the nanoparticles in the flocculation always remained at 7–9 nm, which ensured the high stability and sensitivity of the FLERS method. We successfully applied FLERS to the in situ noninvasive probing of cupping effect substances. The results indicated the scientific principle behind the traditional Chinese medicine method to some extent, which thus provides a new and effective method for the in situ dynamic monitoring of biological systems.

Graphical abstract: Insight into ultrasensitive and high-stability flocculation-enhanced Raman spectroscopy for the in situ noninvasive probing of cupping effect substances

Supplementary files

Article information

Article type
Paper
Submitted
02 Jun 2022
Accepted
24 Jun 2022
First published
08 Jul 2022

Analyst, 2022,147, 3456-3463

Insight into ultrasensitive and high-stability flocculation-enhanced Raman spectroscopy for the in situ noninvasive probing of cupping effect substances

M. Ge, X. Zhang, G. Zhou, S. Chen, Z. Wu, L. Li, Y. Nie, Y. Wang, Y. Yu, D. Lin, P. Li and L. Yang, Analyst, 2022, 147, 3456 DOI: 10.1039/D2AN00916A

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