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GUT IMMUNOMETABOLISM

Keeping ILCs in shape: PD-1 as a metabolic checkpoint

Nature Metabolism volume 4, pages 794–795 (2022)Cite this article

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Anti-PD-1 immunotherapy has emerged as a revolutionary therapeutic strategy against cancer. However, it often leads to undesired side effects. In this issue, a new study reports how PD-1 signalling drives metabolic dysregulation in colonic lymphoid tissue inducer cells, thus contributing to the development of intestinal inflammation.

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Fig. 1: PD-1 regulates the cellular metabolism of lymphoid tissue inducer (LTi) cells.

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Authors and Affiliations

  1. Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany

    Laura Surace

  2. Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany

    Christoph Wilhelm

Authors
  1. Laura Surace
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  2. Christoph Wilhelm
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Correspondence to Laura Surace or Christoph Wilhelm.

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The authors declare no competing interests.

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Surace, L., Wilhelm, C. Keeping ILCs in shape: PD-1 as a metabolic checkpoint. Nat Metab 4, 794–795 (2022). https://doi.org/10.1038/s42255-022-00599-5

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