Gamma-glutamyltransferase is a strong predictor of secondary sclerosing cholangitis after lung transplantation for COVID-19 ARDS

https://doi.org/10.1016/j.healun.2022.06.020Get rights and content
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Background

Lung transplantation (LTx) can be considered for selected patients suffering from COVID-19 acute respiratory distress syndrome (ARDS). Secondary sclerosing cholangitis in critically ill (SSC-CIP) patients has been described as a late complication in COVID-19 ARDS survivors, however, rates of SSC-CIP after LTx and factors predicting this detrimental sequela are unknown.

Methods

This retrospective analysis included all LTx performed for post-COVID ARDS at 8 European LTx centers between May 2020 and January 2022. Clinical risk factors for SSC-CIP were analyzed over time. Prediction of SSC-CIP was assessed by ROC-analysis.

Results

A total of 40 patients were included in the analysis. Fifteen patients (37.5%) developed SSC-CIP. GGT at the time of listing was significantly higher in patients who developed SSC-CIP (median 661 (IQR 324-871) vs 186 (109-346); p = 0.001). Moreover, higher peak values for GGT (585 vs 128.4; p < 0.001) and ALP (325 vs 160.2; p = 0.015) were found in the ‘SSC’ group during the waiting period. Both, GGT at the time of listing and peak GGT during the waiting time, could predict SSC-CIP with an AUC of 0.797 (95% CI: 0.647-0.947) and 0.851 (95% CI: 0.707-0.995). Survival of ‘SSC’ patients was severely impaired compared to ‘no SSC’ patients (1-year: 46.7% vs 90.2%, log-rank p = 0.004).

Conclusions

SSC-CIP is a severe late complication after LTx for COVID-19 ARDS leading to significant morbidity and mortality. GGT appears to be a sensitive parameter able to predict SSC-CIP even at the time of listing.

KEYWORDS

Covid-19
lung transplantation
secondary sclerosing cholangitis
critically ill patients
liver

Abbreviations

ALAT
Alanine aminotransferase
ALP
Alkaline phosphatase
ARDS
Acute respiratory distress syndrome
ASAT
Aspartate aminotransferase
AUC
Area under the curve
COVID-19
Coronavirus disease 2019
ECLS
Extracorporeal live support
ECMO
Extracorporeal membrane oxygenation
GGT
Gamma-glutamyltransferase
ICU
Intensive care unit
IQR
Inter-quartile range
LAS
Lung allocation score
LTx
Lung transplantation
mg/dL
Milligrams per deciliter
PEEP
Positive end-expiratory pressure
PGD
Primary graft dysfunction
POD
Post-operative day
ROC
Receiver operating characteristic
SSC-CIP
Secondary sclerosing cholangitis in critically ill patients
TBi
Total bilirubin
U/L
Units per liter

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