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The Alzheimer’s disease GWAS risk alleles in the ABCA7 promoter and 5’ region reduce ABCA7 expression

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References

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Acknowledgements

The authors thank Drs. Bernard Ng and Biao Zeng for help with data interpretation and Jared Nedzel at GTEx for suggesting a workaround to obtain required statistical measures. This work was supported by the National Institute on Aging grant AG070512 to N.N.L. and Pennsylvania Department of Health Commonwealth Universal Research Enhancement Program award 4100083099 to D.P.

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Authors and Affiliations

  1. Alzheimer’s Center at Temple, Department of Neural Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA

    Nicholas N. Lyssenko & Domenico Praticò

  2. Department of Computer & Information Sciences, College of Science and Technology, Temple University, Philadelphia, PA, USA

    Xinghua Shi

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  1. Nicholas N. Lyssenko
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  2. Xinghua Shi
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  3. Domenico Praticò
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Correspondence to Nicholas N. Lyssenko or Domenico Praticò.

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Lyssenko, N.N., Shi, X. & Praticò, D. The Alzheimer’s disease GWAS risk alleles in the ABCA7 promoter and 5’ region reduce ABCA7 expression. Acta Neuropathol 144, 585–587 (2022). https://doi.org/10.1007/s00401-022-02459-8

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