Multiple methods for deriving human cortical organoids have been established in the past decade. A study now systematically compares patterning strategies and shows that combined WNT and dual SMAD inhibition is superior to dual SMAD inhibition alone in inducing robust cortical identity in 3D human pluripotent stem-cell aggregates.
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Atamian, A., Birtele, M. & Quadrato, G. Not all cortical organoids are created equal. Nat Cell Biol 24, 805–806 (2022). https://doi.org/10.1038/s41556-022-00890-3
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DOI: https://doi.org/10.1038/s41556-022-00890-3
