Human naive pluripotent stem cells are generally believed to possess an unrestricted capacity to differentiate into both embryonic and extraembryonic lineages. However, two new studies now uncover a role for the Polycomb repressive complex 2 (PRC2) as a lineage gatekeeper that shields the potency of these cells.
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References
Rossant, J. & Tam, P. P. L. Dev. Cell 57, 152–165 (2022).
Zijlmans, D. W. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-022-00932-w (2022).
Kumar, B. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-022-00916-w (2022).
De Paepe, C. et al. Hum. Reprod. 28, 740–749 (2013).
Guo, G. et al. Cell Stem Cell 28, 1040–1056.E6 (2021).
Dong, C. et al. Elife 9, e52504 (2020).
Cinkornpumin, J. K. et al. Stem Cell Rep. 15, 198–213 (2020).
Io, S. et al. Cell Stem Cell 28, 1023–1039.E13 (2021).
Pera, M. F. & Rossant, J. Cell Stem Cell 28, 1896–1906 (2021).
Cavalli, G. & Heard, E. Nature 571, 489–499 (2019).
Schuettengruber, B., Bourbon, H. M., Di Croce, L. & Cavalli, G. Cell 171, 34–57 (2017).
Shan, Y. et al. Nat. Commun. 8, 672 (2017).
Moody, J. D. et al. Proc. Natl Acad. Sci. USA 114, 10125–10130 (2017).
Chammas, P., Mocavini, I. & Di Croce, L. Br. J. Cancer 122, 315–328 (2020).
Youmans, D. T., Gooding, A. R., Dowell, R. D. & Cech, T. R. Mol. Cell 81, 488–501.e9 (2021).
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Aranda, S., Condemi, L. & Di Croce, L. PRC2 shields the potency of human stem cells. Nat Cell Biol 24, 806–808 (2022). https://doi.org/10.1038/s41556-022-00937-5
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DOI: https://doi.org/10.1038/s41556-022-00937-5