Short CommunicationSynthesis of 3-thiocyanated chromones via TCCA/NH4SCN-mediated cyclization/thiocyanation of alkynyl aryl ketones
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Graphical abstract
3-Thiocyanated chromones were conveniently synthesized from alkynyl aryl ketones using commercially available, inexpensive TCCA as oxidant and NH4SCN as thiocyanato (SCN) source. This metal-free approach is postulated to first in situ generate thiocyanogen chloride (Cl-SCN) from the reaction of TCCA and NH4SCN, followed by a rare efficient electrophilic thiocyano oxyfunctionalization of alkynes enabled by the reactive electrophilic species generated thereof.
Keywords
Thiocyanation
Cyclization
TCCA
NH4SCN
Chromones
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These two authors contributed equally to this work.
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