The efficacy of the use of heparin in the emergency room in patients with acute ST-segment elevation myocardial infarction

Abstract

Aim

To investigate the efficacy of the use of heparin in the emergency room in patients with acute ST-segment elevation myocardial infarction (STEMI).

Methods

200 STEMI patients undergoing primary percutaneous coronary intervention (PCI) were randomly divided into the research and control groups (heparin administration in emergency room and catheterization laboratory, respectively).

Results

The rate of thrombolysis in myocardial infarction (TIMI) grade 2 flow in the research participants was significantly higher than that in the controls (P < 0.05). The stent diameter in the research patients was smaller than that in the control participants (P < 0.05); while the stent length in the research patients was shorter than that in the controls (P < 0.05). The slow flow rate in the research patients was similar to that in the control participants (P > 0.05). There were no differences between the groups in the corrected TIMI frame counts or intraoperative complications (P > 0.05). The ST-segment resolution rate within 2 h post-PCI was 90.0% in the research patients and 83.8% in the controls (P > 0.05). There was no significant difference in the cardiac troponin and N terminal prohormone of brain natriuretic peptide (NT-proBNP) levels between the two groups post-PCI (P > 0.05). The left ventricular end-diastolic volume and left ventricular ejection fraction (LVEF) during hospitalization were similar between the groups (P > 0.05).

Conclusion

Administering heparin to STEMI patients in the emergency room can increase the rate of coronary artery revascularization.