Eur J Pediatr Surg 2023; 33(04): 287-292
DOI: 10.1055/a-1868-6224
Original Article

Preoperative Metal Patch Testing and Titanium Bar Use Criteria in Nuss Procedure: A 56-Patients' Cohort Study

1   Department of Pediatrics, Centro Hospitalar Universitário de São João Ringgold Standard Institution, Porto, Porto, Portugal
2   Department of Gynecology-Obstetrics and Pediatrics, Faculty of Medicine, University of Porto, Porto, Portugal
,
3   Department of Pediatric Surgery, Centro Hospitalar Universitário de São João Ringgold Standard Institution, Porto, Portugal
,
José Fontoura-Matias
1   Department of Pediatrics, Centro Hospitalar Universitário de São João Ringgold Standard Institution, Porto, Porto, Portugal
2   Department of Gynecology-Obstetrics and Pediatrics, Faculty of Medicine, University of Porto, Porto, Portugal
,
Nuno Preto-Gomes
4   Department of Dermatology, Centro Hospitalar Universitário de São João Ringgold Standard Institution, Porto, Porto, Portugal
,
Ana Marinho-Cunha
4   Department of Dermatology, Centro Hospitalar Universitário de São João Ringgold Standard Institution, Porto, Porto, Portugal
,
Miguel Soares-Oliveira
3   Department of Pediatric Surgery, Centro Hospitalar Universitário de São João Ringgold Standard Institution, Porto, Portugal
› Author Affiliations

Abstract

Introduction Nuss procedure is the main reason for metal implants use by pediatric and thoracic surgeons. There is an ongoing debate on how to avoid allergic complications. Herein we describe our 8-year experience with systematic preoperative metal patch testing and our selective titanium bar use in Nuss procedure.

Materials and Methods This is a single center retrospective observational cohort study of patients who underwent the Nuss procedure from 2013 to 2020. Preoperative metal patch testing was done in all cases. Criteria for titanium bar utilization were: a positive test for a major component of the stainless-steel bar; or a positive metal patch test and a positive history of atopy, food or metal allergy, or previous allergic reaction to an implant or device.

Results In total, 56 patients were included. Most were male (91.1%) with a median age of 15.0 (13.0–22.0) years old. 19.6% had a positive preoperative metal patch test and 54.5% of these had no personal history of atopy. Stainless-steel bars were used in 27.3% of those patients and titanium bars were used in 72.7%. One patient had a documented minor allergy reaction. None of the 56 patients required early bar removal.

Conclusion Our study suggests that routine preoperative allergy testing and a judicious use of titanium bar are safe and avoid metal allergic complications.

Supplementary Material



Publication History

Received: 10 March 2022

Accepted: 31 May 2022

Accepted Manuscript online:
03 June 2022

Article published online:
14 October 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Mayer OH. Pectus excavatum: Treatment. In: Post TW, ed. UpToDate. Waltham, MA: UpToDate. [Accessed on March 21, 2021]
  • 2 Nuss D. Minimally invasive surgical repair of pectus excavatum. Semin Pediatr Surg 2008; 17 (03) 209-217
  • 3 Heitmiller K, French A, Alaish SM, Goldner R, Gaspari AA. Patch testing for metal allergy with manufacturer-supplied materials before Nuss bar insertion. Dermatitis 2015; 26 (06) 271-275
  • 4 Shah B, Cohee A, Deyerle A. et al. High rates of metal allergy amongst Nuss procedure patients dictate broader pre-operative testing. J Pediatr Surg 2014; 49 (03) 451-454
  • 5 Rushing GD, Goretsky MJ, Gustin T, Morales M, Kelly Jr RE, Nuss D. When it is not an infection: metal allergy after the Nuss procedure for repair of pectus excavatum. J Pediatr Surg 2007; 42 (01) 93-97
  • 6 Schalock PC, Menné T, Johansen JD. et al. Hypersensitivity reactions to metallic implants - diagnostic algorithm and suggested patch test series for clinical use. Contact Dermat 2012; 66 (01) 4-19
  • 7 Sesia SB, Haecker F-M, Shah B, Goretsky MJ, Kelly RE, Obermeyer RJ. Development of metal allergy after Nuss procedure for repair of pectus excavatum despite preoperative negative skin test. J Pediatr Surg Case Rep 2013; 1 (06) 152-155
  • 8 Gałązka P, Leis K, Kroczek K, Baska A, Kazik J, Czajkowski R. Metal allergy after the Nuss procedure for pectus excavatum: a review. Postepy Dermatol Alergol 2020; 37 (06) 848-852
  • 9 Aneja S, Taylor JS, Soldes O, DiFiore J. Dermatitis in patients undergoing the Nuss procedure for correction of pectus excavatum. Contact Dermat 2011; 65 (06) 317-321
  • 10 Schalock PC, Crawford G, Nedorost S. et al. Patch testing for evaluation of hypersensitivity to implanted metal devices: a perspective from the American Contact Dermatitis Society. Dermatitis 2016; 27 (05) 241-247
  • 11 Thyssen JP, Menné T, Schalock PC, Taylor JS, Maibach HI. Pragmatic approach to the clinical work-up of patients with putative allergic disease to metallic orthopaedic implants before and after surgery. Br J Dermatol 2011; 164 (03) 473-478
  • 12 Saxena AK. Chest Wall Deformities. Berlin: Springer; 2017: 307-311
  • 13 Rosner GA, Fonacier LS. Hypersensitivity to biomedical implants: prevention and diagnosis. Allergy Asthma Proc 2017; 38 (03) 177-183
  • 14 Johansen JD, Aalto-Korte K, Agner T. et al. European Society of Contact Dermatitis guideline for diagnostic patch testing—recommendations on best practice. Contact Dermat 2015; 73 (04) 195-221
  • 15 Johansen JD, Mahler V, Lepoittevin J-P, Frosch PJ. Contact Dermatitis. 6th ed. Switzerland: Springer; 2021
  • 16 Magnusson B, Blohm SG, Fregert S. et al. Routine patch testing. II. Proposed basic series of test substances for Scandinavian countries and general remarks on testing technique. Acta Derm Venereol 1966; 46 (02) 153-158
  • 17 Vilaça JL, Rodrigues PL, Soares TR. et al. Automatic prebent customized prosthesis for pectus excavatum minimally invasive surgery correction. Surg Innov 2014; 21 (03) 290-296
  • 18 Schalock PC, Thyssen JP. Patch testers' opinions regarding diagnostic criteria for metal hypersensitivity reactions to metallic implants. Dermatitis 2013; 24 (04) 183-185
  • 19 Rietschel RL, Fowler JF. Fisher's Contact Dermatitis. 6 ed. Hamilton: BC Decker Inc; 2008
  • 20 Obermeyer RJ, Gaffar S, Kelly Jr RE. et al. Selective versus routine patch metal allergy testing to select bar material for the Nuss procedure in 932 patients over 10years. J Pediatr Surg 2018; 53 (02) 260-264
  • 21 Kelly RE, Goretsky MJ, Obermeyer R. et al. Twenty-one years of experience with minimally invasive repair of pectus excavatum by the Nuss procedure in 1215 patients. Ann Surg 2010; 252 (06) 1072-1081
  • 22 Fischer LA, Menné T, Johansen JD. Experimental nickel elicitation thresholds—a review focusing on occluded nickel exposure. Contact Dermat 2005; 52 (02) 57-64
  • 23 Thomas P, Bandl WD, Maier S, Summer B, Przybilla B. Hypersensitivity to titanium osteosynthesis with impaired fracture healing, eczema, and T-cell hyperresponsiveness in vitro: case report and review of the literature. Contact Dermat 2006; 55 (04) 199-202
  • 24 Sakamoto K, Ando K, Noma D. Metal allergy to titanium bars after the Nuss procedure for pectus excavatum. Ann Thorac Surg 2014; 98 (02) 708-710
  • 25 Bouchard ME, Petrosyan M, Kane TD. Case series of metal allergy following Nuss procedure: not only for stainless steel bars. J Pediatr Surg 2021; 56 (11) 1976-1981
  • 26 Haddad SF, Helm MM, Meath B, Adams C, Packianathan N, Uhl R. Exploring the incidence, implications, and relevance of metal allergy to orthopaedic surgeons. J Am Acad Orthop Surg Glob Res Rev 2019; 3 (04) e023